Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 1/20 | 0.44 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.43 |
| ▸ | TYMP | P19971 | 1/20 | 0.42 |
| ▸ | TYMS | P04818 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9780827 | 1.00 | TK1 (0.44) | TK1RNASE1TYMPTYMS | |
| SCHEMBL9780967 | 0.92 | TK1 (0.46) | TK1RNASE1TYMP | |
| SCHEMBL9780963 | 0.92 | TK1 (0.46) | TK1RNASE1TYMP | |
| SCHEMBL9100246 | 0.88 | HSP90AA1 (0.54) | TK1RNASE1TYMPTYMS | |
| SCHEMBL10694464 | 0.88 | TYMS (0.44) | TK1RNASE1TYMPTYMS | |
| SCHEMBL9100241 | 0.88 | HSP90AA1 (0.54) | TK1RNASE1TYMPTYMS | |
| SCHEMBL10694460 | 0.88 | TYMS (0.44) | TK1RNASE1TYMPTYMS | |
| SCHEMBL10694863 | 0.88 | TK1 (0.47) | TK1RNASE1TYMPTYMS | |
| SCHEMBL10693954 | 0.88 | TK1 (0.47) | TK1RNASE1TYMPTYMS | |
| SCHEMBL10693997 | 0.87 | LMNA (0.50) | TK1RNASE1TYMPTYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257378-B1 | PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1991-07-03 | — | — | EP | disclosed |
| US-5010060-A | Method of treating herpes simplex viral infection employing pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-04-23 | — | — | US | disclosed |
| US-4851519-A | AMIDO NUCLEOSIDES, VIRICIDES | HOFFMANN-LA ROCHE INC. (US) | 1989-07-25 | — | — | US | disclosed |