Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 4/20 | 0.53 |
| ▸ | TK2 | O00142 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ALB | P02768 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2035886 | 1.00 | TK1 (0.53) | TK1TK2LMNAALBALDH1A1 | |
| SCHEMBL10378935 | 0.91 | TK1 (0.65) | TK1TK2LMNAALBALDH1A1 | |
| SCHEMBL10523542 | 0.91 | TK1 (0.65) | TK1TK2LMNAALBALDH1A1 | |
| SCHEMBL13497225 | 0.91 | TK1 (0.48) | TK1TK2LMNAALBALDH1A1 | |
| SCHEMBL13366956 | 0.88 | TK1 (0.46) | TK1TK2LMNAALBALDH1A1 | |
| SCHEMBL9780924 | 0.87 | TK1 (0.45) | TK1TK2 | |
| SCHEMBL9780930 | 0.87 | TK1 (0.45) | TK1TK2 | |
| SCHEMBL14596607 | 0.86 | LMNA (0.58) | TK1LMNAALBALDH1A1TSHR | |
| SCHEMBL762579 | 0.86 | LMNA (0.58) | TK1LMNAALBALDH1A1TSHR | |
| SCHEMBL22992337 | 0.86 | LMNA (0.58) | TK1LMNAALBALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4968788-A | DRUG DELIVERY, ANTITUMOR AGENTS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1990-11-06 | — | — | US | claimed |
| US-5010060-A | Method of treating herpes simplex viral infection employing pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-04-23 | — | — | US | disclosed |
| WO-1990003978-A1 | 5-HALOGENO-3'-FLUORO-2',3'-DIDEOXYURIDINE COMPOUNDS AND THEIR THERAPEUTIC APPLICATION | STICHTING REGA VZW (BE) | 1990-04-19 | — | — | WO | disclosed |
| US-4866036-A | ENHANCE RESISTANCE TO OPPORTUNISTIC INFECTIONS IN COMBINATION WITH AIDS VIRICIDE | MERCK & CO., INC. (US) | 1989-09-12 | — | — | US | disclosed |
| US-4851519-A | AMIDO NUCLEOSIDES, VIRICIDES | HOFFMANN-LA ROCHE INC. (US) | 1989-07-25 | — | — | US | disclosed |
| US-4841039-A | 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents | EMORY UNIVERSITY (US) | 1989-06-20 | — | — | US | disclosed |
| EP-0316592-A2 | 3'-Fluoro-2',3'-dideoxyuridine, and its therapeutic application | Stichting REGA V.Z.W. (BE) | 1989-05-24 | — | — | EP | disclosed |
| US-4681933-A | 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1987-07-21 | — | — | US | disclosed |