Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.51 |
| ▸ | KDM5A | P29375 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TLR4 | O00206 | 1/20 | 0.49 |
| ▸ | TLR2 | O60603 | 1/20 | 0.49 |
| ▸ | EPOR | P19235 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9781079 | 1.00 | ALOX15 (0.65) | ALOX15ALOX5PTGS1PTGS2SMN1; SMN2 | |
| SCHEMBL9781083 | 1.00 | ALOX15 (0.65) | ALOX15ALOX5PTGS1PTGS2SMN1; SMN2 | |
| SCHEMBL9514620 | 0.89 | ALOX15 (0.50) | ALOX15ALOX5PTGS1PTGS2SMN1; SMN2 | |
| SCHEMBL9781107 | 0.89 | TRPA1 (0.59) | ALOX15ALOX5PTGS1PTGS2SMN1; SMN2 | |
| SCHEMBL9781100 | 0.89 | TRPA1 (0.59) | ALOX15ALOX5PTGS1PTGS2SMN1; SMN2 | |
| SCHEMBL9514631 | 0.89 | ALOX15 (0.50) | ALOX15ALOX5PTGS1PTGS2SMN1; SMN2 | |
| SCHEMBL9514622 | 0.89 | ALOX15 (0.50) | ALOX15ALOX5PTGS1PTGS2SMN1; SMN2 | |
| SCHEMBL9781055 | 0.81 | ALOX5 (0.70) | ALOX5PTGS1PTGS2SMN1; SMN2NPC1 | |
| SCHEMBL9781059 | 0.81 | ALOX5 (0.70) | ALOX5PTGS1PTGS2SMN1; SMN2NPC1 | |
| SCHEMBL14667486 | 0.80 | ALOX15 (1.00) | ALOX15SMN1; SMN2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988733-A | Also used in treatment of cardiovascular disorders and inflammation | BURROUGHS WELLCOME CO. (US) | 1991-01-29 | — | — | US | disclosed |