Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9514622 | 1.00 | ALOX15 (0.50) | ALOX15SMN1; SMN2ALOX5ALDH1A1HPGD | |
| SCHEMBL9514620 | 1.00 | ALOX15 (0.50) | ALOX15SMN1; SMN2ALOX5ALDH1A1HPGD | |
| SCHEMBL9781083 | 0.89 | ALOX15 (0.65) | ALOX15SMN1; SMN2ALOX5ALDH1A1PTGS1 | |
| SCHEMBL9781077 | 0.89 | ALOX15 (0.65) | ALOX15SMN1; SMN2ALOX5ALDH1A1PTGS1 | |
| SCHEMBL9781079 | 0.89 | ALOX15 (0.65) | ALOX15SMN1; SMN2ALOX5ALDH1A1PTGS1 | |
| SCHEMBL9781107 | 0.86 | TRPA1 (0.59) | ALOX15SMN1; SMN2ALOX5ALDH1A1HPGD | |
| SCHEMBL9781100 | 0.86 | TRPA1 (0.59) | ALOX15SMN1; SMN2ALOX5ALDH1A1HPGD | |
| SCHEMBL9514221 | 0.83 | ALOX5 (0.56) | SMN1; SMN2ALOX5ALDH1A1HPGDPTGS1 | |
| SCHEMBL9514207 | 0.83 | ALOX5 (0.56) | SMN1; SMN2ALOX5ALDH1A1HPGDPTGS1 | |
| SCHEMBL8783371 | 0.79 | ALDH1A1 (0.57) | SMN1; SMN2ALOX5ALDH1A1HPGDPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384594-B1 | Anti-inflammatory aryl derivatives | WELLCOME FOUND (GB) | 1993-10-27 | — | — | EP | disclosed |
| EP-0299761-B1 | ANTI-INFLAMMATORY ARYL DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-12-18 | — | — | EP | disclosed |
| US-4988733-A | Also used in treatment of cardiovascular disorders and inflammation | BURROUGHS WELLCOME CO. (US) | 1991-01-29 | — | — | US | disclosed |
| EP-0384594-A1 | Anti-inflammatory aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-08-29 | — | — | EP | disclosed |
| EP-0299761-A1 | Anti-inflammatory aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1989-01-18 | — | — | EP | disclosed |