Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 7/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | ATP4A | P20648 | 2/20 | 0.40 |
| ▸ | ATP4B | P51164 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9788974 | 0.89 | KLKB1 (0.47) | KLKB1LMNAHTTHTR6DRD2 | |
| SCHEMBL9788986 | 0.87 | KLKB1 (0.48) | KLKB1LMNAHTTHTR6MEN1 | |
| SCHEMBL9788970 | 0.83 | LMNA (0.56) | KLKB1LMNAHTTHTR6DRD2 | |
| SCHEMBL1156845 | 0.83 | TSHR (0.51) | KLKB1LMNAHTTMEN1KMT2A | |
| SCHEMBL9789023 | 0.77 | KLKB1 (0.45) | KLKB1LMNAHTTHTR6MEN1 | |
| SCHEMBL27622290 | 0.74 | LMNA (0.72) | LMNAHTR6DRD2MEN1KMT2A | |
| SCHEMBL1156730 | 0.74 | HTR6 (0.46) | KLKB1LMNAHTTHTR6DRD2 | |
| SCHEMBL27233758 | 0.71 | LMNA (0.64) | LMNAMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL15561093 | 0.71 | TSHR (0.50) | LMNAHTTHTR6MEN1KMT2A | |
| SCHEMBL4962809 | 0.70 | TSHR (0.47) | LMNAHTTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259085-B1 | 2-GUANIDINO-4-ARYLTHIAZOLES FOR TREATMENT OF PEPTIC ULCERS | PFIZER INC. (US) | 1991-08-21 | — | — | EP | disclosed |
| US-5026715-A | 2-guanidino-4-arylthiazoles for treatment of peptic ulcers | PFIZER INC. (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0259085-A1 | 2-Guanidino-4-arylthiazoles for treatment of peptic ulcers | PFIZER INC. (US) | 1988-03-09 | — | — | EP | disclosed |