SCHEMBL9790141

SCHEMBL9790141

Cc1cccc(N2CCNCC2)c1C(F)(F)F

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB1 P08588 4/20 0.63
HTR7 P34969 3/20 0.55
HTR3A P46098 8/20 0.51
HTR1A P08908 7/20 0.51
CYP1A2 P05177 3/20 0.51
CYP2D6 P10635 3/20 0.51
CYP3A4 P08684 2/20 0.51
CYP2C9 P11712 2/20 0.51
NCF1 P14598 2/20 0.48
HTR3E A5X5Y0 2/20 0.46
HTR3B O95264 2/20 0.46
HTR1D P28221 2/20 0.46
HTR3D Q70Z44 2/20 0.46
HTR3C Q8WXA8 2/20 0.46
SIGMAR1 Q99720 2/20 0.46
ALDH1A1 P00352 1/20 0.46
HTR2C P28335 1/20 0.46
DRD2 P14416 1/20 0.46
DRD3 P35462 1/20 0.46
TSHR P16473 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13287306 0.83 GAA (0.46) ADRB1ALDH1A1TSHR
SCHEMBL3218230 0.82 HTR3A (0.47) ADRB1HTR7HTR3AHTR1ACYP1A2
SCHEMBL4727692 0.81 ADRB1 (0.64) ADRB1HTR7HTR3AHTR1ACYP1A2
SCHEMBL8528737 0.80 HTR3A (0.65) ADRB1HTR7HTR3AHTR1AHTR3E
Hydrochloric Acid SCHEMBL4725829 0.79 ADRB1 (0.62) ADRB1HTR7HTR3AHTR1ACYP1A2
SCHEMBL16276119 0.78 ADRB1 (0.69) ADRB1HTR7HTR3AHTR1ACYP1A2
SCHEMBL29057988 0.78 HTR1A (0.46) ADRB1HTR7HTR3AHTR1ACYP1A2
SCHEMBL30395008 0.78 HTR1A (0.46) ADRB1HTR7HTR3AHTR1ACYP1A2
SCHEMBL30395039 0.78 HTR6 (0.55) ADRB1HTR3AHTR1ACYP1A2CYP2D6
SCHEMBL28311526 0.78 HTR6 (0.55) ADRB1HTR3AHTR1ACYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5075488-A Fungicides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1991-12-24 US disclosed
EP-0128006-B1 A SOIL-DISEASE-CONTROLLING AGENT SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1991-09-18 EP disclosed
US-4709052-A FUNGICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1987-11-24 US disclosed
EP-0128006-A2 A soil-disease-controlling agent SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-12-12 EP disclosed
US-4397855-A 4-(Substituted)-α, α-dimethyl-1-piperazine pentanoic acids and derivatives as anti-arteriosclerotic agents and method WARNER-LAMBERT COMPANY (US) 1983-08-09 US disclosed