Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | GAA | P10253 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | GFER | P55789 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9790564 | 0.99 | FDPS (0.56) | FDPSMAPTGAAKDM4EALDH1A1 | |
| SCHEMBL9790580 | 0.91 | MAPT (0.49) | FDPSMAPTGAAKDM4EALDH1A1 | |
| SCHEMBL1745407 | 0.76 | MEN1 (0.60) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL19134400 | 0.75 | ROCK2 (0.56) | MAPTGAAKDM4EALDH1A1LMNA | |
| Phosphonic Acid SCHEMBL9790585 | 0.74 | MAPT (0.49) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL9790870 | 0.73 | ADORA3 (0.58) | FDPSMAPTLMNAMEN1KMT2A | |
| SCHEMBL9745549 | 0.73 | MAPT (0.67) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL12678090 | 0.73 | ELOVL1 (0.60) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL9745568 | 0.73 | MAPT (0.67) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL10700452 | 0.73 | MAPT (0.49) | MAPTGAAKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274346-A1 | Substituted aminomethane-diphosphonic acids | CIBA-GEIGY AG (CH) | 1988-07-13 | — | — | EP | claimed |
| US-5057505-A | Treatment of illnesses attributed to calcium metabolism disorders | CIBA-GEIGY CORPORATION (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0282309-A2 | Azole-aminomethylene bisphosphonic acid derivatives | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1988-09-14 | — | — | EP | disclosed |