Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12036809 | 0.78 | PDE4A (0.40) | PDE4ACYP1A2CYP2C19HTR1ADRD2 | |
| SCHEMBL7935983 | 0.75 | PDE4A (0.35) | PDE4ACYP1A2CYP2C19LMNA | |
| SCHEMBL10994004 | 0.74 | HTR1A (0.57) | PDE4ACYP1A2CYP2C19HTR1ADRD2 | |
| SCHEMBL33146 | 0.73 | PDE4A (0.48) | PDE4ACYP1A2CYP2C19LMNA | |
| SCHEMBL410475 | 0.73 | PDE4A (0.70) | PDE4ACYP1A2CYP2C19LMNAPOLB | |
| SCHEMBL2242634 | 0.73 | PDE4A (0.62) | PDE4ACYP1A2CYP2C19LMNAPOLB | |
| SCHEMBL14220773 | 0.72 | PDE4A (0.36) | PDE4ACYP1A2CYP2C19HTR1ADRD2 | |
| SCHEMBL27655564 | 0.72 | PDE4A (0.36) | PDE4ACYP1A2CYP2C19HTR1ADRD2 | |
| SCHEMBL11168320 | 0.72 | ADORA1 (0.47) | PDE4A | |
| SCHEMBL27871771 | 0.70 | PDE4A (0.46) | PDE4ACYP1A2CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8802672-B2 | Pyrimidinyl-piperazines useful as D3/D2 receptor ligands | RICHTER GEDEON NYRT. (HU) | 2014-08-12 | — | — | US | disclosed |
| WO-2014080341-A1 | NEW PROCESS FOR THE SYNTHESIS OF TRICHLOROPYRIMIDINE-AMINE DERIVATIVES | RICHTER GEDEON NYRT. (HU) | 2014-05-30 | — | — | WO | disclosed |
| EP-2132185-B1 | PYRIMIDINYL-PIPERAZINES USEFUL AS DOPAMINE D3/D2 RECEPTOR LIGANDS | RICHTER GEDEON NYRT (HU) | 2011-08-03 | — | — | EP | disclosed |
| US-20110112093-A1 | PYRIMIDINYL-PIPERAZINES USEFUL AS D3/D2 RECEPTOR LIGANDS | RICHTER GEDEON NYRT. | 2011-05-12 | — | — | US | disclosed |
| US-7875610-B2 | trans-N-(4-{2-[4-(5,6-dichloro-2-methylamino-pyrimidin-4-yl)-piperazin-1-yl]-ethyl]-cyclohexyl}-acetamide; for treating Parkinson's disease; reacting trans-(4-{4-[2-(4-amino-cyclohexyl)-ethyl]-piperazin-1-yl}-5,6-dichloro-pyrimidin-2-yl)-methyl-amine trihydrochloride with acetyl chloride | RICHTER GEDEON NYRT. (HU) | 2011-01-25 | — | — | US | disclosed |
| EP-2132185-A2 | PYRIMIDINYL-PIPERAZINES USEFUL AS DOPAMINE D3/D2 RECEPTOR LIGANDS | Richter Gedeon NYRT (HU) | 2009-12-16 | — | — | EP | disclosed |
| US-20090143398-A1 | PYRIMIDINYL-PIPERAZINES USEFUL AS D3/D2 RECEPTOR LIGANDS | RICHTER GEDEON NYRT. (HU) | 2009-06-04 | — | — | US | disclosed |
| WO-2008125891-A2 | PYRIMIDINYL-PIPERAZINES USEFUL AS DOPAMINE D3 /D2 RECEPTOR LIGANDS | RICHTER GEDEON NYRT (HU) | 2008-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112093-A1 | PYRIMIDINYL-PIPERAZINES USEFUL AS D3/D2 RECEPTOR LIGANDS | DRD2, DRD3, AVPR2 | PDE4A 653/4885CYP1A2 962/4885CYP2C19 1023/4885 |
| US-20090143398-A1 | PYRIMIDINYL-PIPERAZINES USEFUL AS D3/D2 RECEPTOR LIGANDS | DRD2, DRD3, AVPR2 | PDE4A 653/4885CYP1A2 962/4885CYP2C19 1023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.