Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9792175 | 0.90 | GRIN1 (0.47) | ALDH1A1KDM4EKMT2ASMN1; SMN2TP53 | |
| SCHEMBL9792183 | 0.89 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL9792182 | 0.86 | BRD4 (0.51) | BRD4 | |
| SCHEMBL9792181 | 0.83 | GRIN1 (0.45) | ALDH1A1KDM4EKMT2ATP53BRD4 | |
| SCHEMBL9792190 | 0.78 | BRD4 (0.52) | ALDH1A1KMT2ATP53BRD4 | |
| SCHEMBL10388634 | 0.70 | — | — | |
| SCHEMBL9792209 | 0.70 | — | — | |
| SCHEMBL10386716 | 0.69 | CYP1A2 (0.53) | ALDH1A1KDM4EMAPK1 | |
| SCHEMBL10573409 | 0.69 | — | — | |
| SCHEMBL15474514 | 0.68 | BRD4 (0.54) | ALDH1A1KDM4EMAPTRAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5066654-A | 2-aryl-3-heterocyclicmethyl-3H-imidazo[4,5-b]pyridines as anxiolytics and anticonvulsants | A. H. ROBINS COMPANY, INCORPORATED (US) | 1991-11-19 | — | — | US | claimed |
| US-5066654-A | 2-aryl-3-heterocyclicmethyl-3H-imidazo[4,5-b]pyridines as anxiolytics and anticonvulsants | A. H. ROBINS COMPANY, INCORPORATED (US) | 1991-11-19 | — | — | US | disclosed |