Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9792182 | 0.88 | BRD4 (0.51) | BRD4 | |
| SCHEMBL9792175 | 0.87 | GRIN1 (0.47) | BRD4GRIN1GRIN2BALDH1A1MEN1 | |
| SCHEMBL9792181 | 0.85 | GRIN1 (0.45) | BRD4GRIN1GRIN2BALDH1A1MEN1 | |
| SCHEMBL2618364 | 0.80 | ALDH1A1 (0.50) | BRD4ALDH1A1MEN1KMT2AAKT1 | |
| SCHEMBL9792185 | 0.79 | BRD4 (0.47) | BRD4ALDH1A1MEN1KMT2AAKT1 | |
| SCHEMBL9792188 | 0.78 | BRD4 (0.46) | BRD4ALDH1A1MEN1KMT2A | |
| SCHEMBL9792178 | 0.78 | ALDH1A1 (0.47) | BRD4ALDH1A1KMT2ATP53 | |
| SCHEMBL9792183 | 0.76 | ALDH1A1 (0.45) | ALDH1A1 | |
| SCHEMBL2618383 | 0.75 | BRD4 (0.53) | BRD4ALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL15474514 | 0.74 | BRD4 (0.54) | BRD4ALDH1A1MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5066654-A | 2-aryl-3-heterocyclicmethyl-3H-imidazo[4,5-b]pyridines as anxiolytics and anticonvulsants | A. H. ROBINS COMPANY, INCORPORATED (US) | 1991-11-19 | — | — | US | claimed |
| US-5066654-A | 2-aryl-3-heterocyclicmethyl-3H-imidazo[4,5-b]pyridines as anxiolytics and anticonvulsants | A. H. ROBINS COMPANY, INCORPORATED (US) | 1991-11-19 | — | — | US | disclosed |