Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | P62805 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9792183 | 0.92 | ALDH1A1 (0.45) | ALDH1A1 | |
| SCHEMBL9792175 | 0.88 | GRIN1 (0.47) | GRIN1GRIN2BMEN1ALDH1A1KMT2A | |
| SCHEMBL9792190 | 0.85 | BRD4 (0.52) | GRIN1GRIN2BMEN1ALDH1A1KMT2A | |
| SCHEMBL9792178 | 0.83 | ALDH1A1 (0.47) | ALDH1A1KMT2ATP53BRD4KDM4E | |
| SCHEMBL9792182 | 0.79 | BRD4 (0.51) | BRD4 | |
| SCHEMBL9792170 | 0.78 | ALDH1A1 (0.39) | MEN1ALDH1A1KMT2ATP53BRD4 | |
| SCHEMBL9693718 | 0.73 | HSD17B10 (0.47) | MEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL9693741 | 0.70 | PLK1 (0.41) | MEN1ALDH1A1KMT2A | |
| SCHEMBL9694163 | 0.70 | NPC1 (0.43) | LMNA | |
| SCHEMBL9792194 | 0.69 | ALDH1A1 (0.39) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5066654-A | 2-aryl-3-heterocyclicmethyl-3H-imidazo[4,5-b]pyridines as anxiolytics and anticonvulsants | A. H. ROBINS COMPANY, INCORPORATED (US) | 1991-11-19 | — | — | US | claimed |
| US-5066654-A | 2-aryl-3-heterocyclicmethyl-3H-imidazo[4,5-b]pyridines as anxiolytics and anticonvulsants | A. H. ROBINS COMPANY, INCORPORATED (US) | 1991-11-19 | — | — | US | disclosed |