Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 2/20 | 0.43 |
| ▸ | CES1 | P23141 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9792276 | 0.81 | ALDH1A1 (0.50) | KMT2ASRD5A2CES2CES1HTT | |
| SCHEMBL9792211 | 0.81 | SRD5A2 (0.50) | KMT2ASRD5A2MAPK1CES2CES1 | |
| SCHEMBL10939169 | 0.79 | SRD5A2 (0.59) | KMT2ASRD5A2MAPK1CES2CES1 | |
| SCHEMBL3164785 | 0.76 | PARP1 (0.33) | KMT2ACES2CES1HTTALOX15 | |
| SCHEMBL11815696 | 0.73 | MMP1 (0.43) | KMT2ASRD5A2MAPK1SMN1; SMN2HTT | |
| SCHEMBL11065553 | 0.73 | SRD5A2 (0.42) | KMT2ASRD5A2MAPK1CES2CES1 | |
| SCHEMBL18646978 | 0.72 | SRD5A2 (0.54) | KMT2ASRD5A2MAPK1CES2CES1 | |
| SCHEMBL10697158 | 0.72 | SRD5A2 (0.80) | SRD5A2MAPK1CES2CES1HTT | |
| SCHEMBL51827 | 0.72 | SRD5A2 (0.80) | SRD5A2MAPK1CES2CES1HTT | |
| SCHEMBL9065412 | 0.72 | SRD5A2 (0.80) | SRD5A2MAPK1CES2CES1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988822-A | Intermediates for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4873340-A | Process for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-A]pyrrole-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1989-10-10 | — | — | US | disclosed |