Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 2/20 | 0.45 |
| ▸ | CES1 | P23141 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.43 |
| ▸ | F3 | P13726 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9792211 | 0.82 | SRD5A2 (0.50) | SRD5A2ALOX15TSHRNR4A1MAPK1 | |
| SCHEMBL10936301 | 0.82 | ALDH1A1 (0.54) | SRD5A2ALOX15TSHRKMT2AMEN1 | |
| SCHEMBL10938785 | 0.81 | SRD5A2 (0.59) | SRD5A2KMT2AMEN1NPC1RAB9A | |
| SCHEMBL9792285 | 0.79 | KMT2A (0.48) | SRD5A2ALOX15TSHRNR4A1MAPK1 | |
| SCHEMBL8732360 | 0.79 | CDC25B (0.55) | SRD5A2MAPK1KMT2AMEN1NPC1 | |
| SCHEMBL7678834 | 0.78 | HPGD (0.48) | SRD5A2ALOX15TSHRNR4A1MAPK1 | |
| SCHEMBL70048 | 0.76 | NFKB1 (0.57) | SRD5A2ALOX15TSHRMAPK1KMT2A | |
| SCHEMBL10943293 | 0.75 | ALDH1A1 (0.59) | SRD5A2TSHRMAPK1KMT2AMEN1 | |
| SCHEMBL4028272 | 0.74 | SRD5A2 (1.00) | SRD5A2ALOX15TSHRNR4A1MAPK1 | |
| SCHEMBL11065553 | 0.74 | SRD5A2 (0.42) | SRD5A2ALOX15TSHRMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |