Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL195020 | 0.79 | SMN1; SMN2 (0.71) | SMN1; SMN2TSHRCASP1SRD5A2HTT | |
| SCHEMBL30185351 | 0.79 | SMN1; SMN2 (0.71) | SMN1; SMN2TSHRCASP1SRD5A2HTT | |
| SCHEMBL7685508 | 0.79 | L3MBTL1 (0.52) | SMN1; SMN2TSHRCASP1SRD5A2HTT | |
| SCHEMBL6168778 | 0.77 | ALOX15 (0.59) | SMN1; SMN2TSHRCASP1SRD5A2HTT | |
| SCHEMBL7682468 | 0.76 | HTT (0.42) | SMN1; SMN2TSHRCASP1SRD5A2HTT | |
| SCHEMBL9653610 | 0.75 | MAPT (0.56) | SMN1; SMN2TSHRCASP1SRD5A2HTT | |
| SCHEMBL11811167 | 0.74 | MAPT (0.49) | HTTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL9792211 | 0.74 | SRD5A2 (0.50) | SMN1; SMN2TSHRSRD5A2HTTMEN1 | |
| SCHEMBL11817628 | 0.73 | RAB9A (0.42) | SMN1; SMN2TSHRCASP1SRD5A2HTT | |
| SCHEMBL9496067 | 0.72 | SRD5A2 (0.79) | SMN1; SMN2TSHRCASP1SRD5A2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988822-A | Intermediates for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4873340-A | Process for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-A]pyrrole-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1989-10-10 | — | — | US | disclosed |