Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 10/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | ATIC | P31939 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9794840 | 0.85 | GART (0.66) | GARTATICMAPT | |
| SCHEMBL9794864 | 0.85 | GART (0.59) | GARTMAPK1LMNACYP1A2CYP3A4 | |
| SCHEMBL9794852 | 0.80 | GART (0.72) | GARTATIC | |
| SCHEMBL9794844 | 0.74 | GART (1.00) | GARTATIC | |
| SCHEMBL7608597 | 0.73 | GART (0.47) | GARTCYP1A2MEN1KMT2AALDH1A1 | |
| SCHEMBL17520101 | 0.71 | TYMS (0.46) | GARTATIC | |
| SCHEMBL9794850 | 0.71 | CA1 (0.51) | MAPK1LMNACYP1A2CYP3A4MAOA | |
| SCHEMBL9038966 | 0.71 | CA12 (0.51) | MAPK1LMNACYP1A2CYP3A4MAOA | |
| SCHEMBL9794867 | 0.71 | GART (0.66) | GARTATICKMT2AALDH1A1MAPT | |
| SCHEMBL20545196 | 0.69 | SMN1; SMN2 (0.55) | LMNACYP1A2CYP3A4MAOAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409382-A1 | Glutamic acid derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-01-23 | — | — | EP | disclosed |
| US-4921836-A | ANTITUMOR AGENTS | BURROUGHS WELLCOME CO. (US) | 1990-05-01 | — | — | US | disclosed |