Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.41 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9795136 | 0.82 | MAPT (0.43) | TSHRTDP1GAAKMT2AMEN1 | |
| SCHEMBL9795208 | 0.81 | MAPT (0.45) | TDP1KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL9498594 | 0.78 | GSTP1 (0.42) | TSHRGAAKMT2AMEN1KDM4E | |
| SCHEMBL9499480 | 0.77 | MAPT (0.44) | TDP1KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL12299330 | 0.76 | HSD17B10 (0.51) | HSD17B10POLBTSHRTDP1KMT2A | |
| Fumaric Acid SCHEMBL9795207 | 0.76 | SLC6A5 (0.37) | TSHRGAAKMT2AMEN1KDM4E | |
| SCHEMBL5605553 | 0.74 | GLA (0.57) | HSD17B10POLBTSHRTDP1KMT2A | |
| Fumaric Acid SCHEMBL9795267 | 0.73 | TSHR (0.40) | TSHRGAAKMT2AMEN1KDM4E | |
| SCHEMBL9795225 | 0.72 | HSD17B10 (0.56) | HSD17B10POLBTSHRTDP1KMT2A | |
| SCHEMBL7095242 | 0.72 | POLB (0.68) | HSD17B10POLBKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037849-A | For treatment of heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1991-08-06 | — | — | US | disclosed |