Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 3/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9795723 | 0.89 | MAPT (0.46) | MAPTMEN1KMT2ASMN1; SMN2HSD17B10 | |
| SCHEMBL9795640 | 0.87 | PDE3B (0.47) | MAPTMEN1KMT2ASMN1; SMN2HSD17B10 | |
| SCHEMBL9795565 | 0.84 | MAPT (0.43) | MAPTMEN1KMT2ASMN1; SMN2HSD17B10 | |
| SCHEMBL9795597 | 0.79 | ALOX5 (0.58) | MAPTMEN1KMT2ASMN1; SMN2HSD17B10 | |
| SCHEMBL9795653 | 0.77 | ALOX5 (0.54) | MAPTMEN1KMT2ASMN1; SMN2HSD17B10 | |
| SCHEMBL9795700 | 0.76 | ALOX5 (0.53) | MAPTMEN1KMT2AALOX5DDB1 | |
| SCHEMBL9796084 | 0.75 | CTSG (0.45) | MAPTALOX5DRD2 | |
| SCHEMBL9795591 | 0.75 | ALOX5 (0.59) | ALOX5DDB1CRBN | |
| SCHEMBL9795641 | 0.73 | ALOX5 (0.60) | MAPTHSD17B10ALOX5 | |
| SCHEMBL9795515 | 0.73 | ALOX5 (0.47) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023255-A | Triazine derivatives; inhibitors exzyme 5-lipoxygenase | GLAXO GROUP LIMITED (GB) | 1991-06-11 | — | — | US | disclosed |
| EP-0388165-A2 | Chemical compounds | GLAXO GROUP LIMITED (GB) | 1990-09-19 | — | — | EP | disclosed |