Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9795597 | 0.87 | ALOX5 (0.58) | ALOX5MAPTCYP1A2SMN1; SMN2HSD17B10 | |
| SCHEMBL9795700 | 0.81 | ALOX5 (0.53) | ALOX5MAPTALDH1A1HPGDMEN1 | |
| SCHEMBL9795641 | 0.76 | ALOX5 (0.60) | ALOX5MAPTHSD17B10 | |
| SCHEMBL9795572 | 0.75 | ALOX5 (0.42) | ALOX5MAPTSMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL9795565 | 0.75 | MAPT (0.43) | ALOX5MAPTSMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL9796084 | 0.75 | CTSG (0.45) | ALOX5MAPT | |
| SCHEMBL9795591 | 0.75 | ALOX5 (0.59) | ALOX5 | |
| SCHEMBL9795595 | 0.74 | ALOX5 (0.59) | ALOX5MAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9795515 | 0.73 | ALOX5 (0.47) | ALOX5 | |
| SCHEMBL9795631 | 0.73 | FAAH (0.44) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023255-A | Triazine derivatives; inhibitors exzyme 5-lipoxygenase | GLAXO GROUP LIMITED (GB) | 1991-06-11 | — | — | US | disclosed |
| EP-0388165-A2 | Chemical compounds | GLAXO GROUP LIMITED (GB) | 1990-09-19 | — | — | EP | disclosed |