Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PTAFR | P25105 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8671570 | 0.81 | POLB (0.40) | MAPTPOLBGAAMTNR1AMTNR1B | |
| SCHEMBL5154300 | 0.81 | POLB (0.38) | MAPTPOLBMEN1KMT2AGAA | |
| SCHEMBL5806535 | 0.80 | POLB (0.41) | MAPTPOLBGAAMTNR1AMTNR1B | |
| SCHEMBL998208 | 0.80 | AKR1C2 (0.46) | ALOX5MAPTPOLBMEN1KMT2A | |
| SCHEMBL5154201 | 0.80 | POLB (0.41) | MAPTPOLBMEN1KMT2AGAA | |
| Hydrochloric Acid SCHEMBL5805761 | 0.79 | KRAS (0.43) | MAPTPOLBGAAMTNR1AMTNR1B | |
| SCHEMBL5809614 | 0.78 | MEN1 (0.40) | MAPTPOLBMEN1KMT2AMTNR1A | |
| SCHEMBL8889810 | 0.78 | POLB (0.39) | MAPTPOLBGAAMTNR1AMTNR1B | |
| SCHEMBL8644241 | 0.77 | POLB (0.40) | MAPTPOLBMEN1KMT2ALMNA | |
| SCHEMBL5805773 | 0.77 | PTGS2 (0.47) | MAPTPOLBMEN1KMT2AMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0374602-A1 | Lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-06-27 | — | — | EP | claimed |
| US-5068251-A | Nonsteroidal antiinflammatory agents, hydroxyurea derivatives | ABBOTT LABORATORIES (US) | 1991-11-26 | — | — | US | disclosed |
| EP-0374602-A1 | Lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-06-27 | — | — | EP | disclosed |