Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL981223 | 0.86 | LTA4H (0.40) | LTA4HRIPK1SLC6A2SLC6A4TSHR | |
| SCHEMBL983439 | 0.83 | LTA4H (0.45) | LTA4HRIPK1SLC6A2SLC6A4HRH1 | |
| SCHEMBL983873 | 0.82 | LTA4H (0.45) | LTA4H | |
| SCHEMBL983948 | 0.81 | LTA4H (0.44) | LTA4H | |
| SCHEMBL4728624 | 0.80 | HTR1A (0.38) | LTA4HSLC6A2SLC6A4TSHRHTT | |
| SCHEMBL4793346 | 0.80 | RIPK1 (0.39) | LTA4HRIPK1SLC6A2SLC6A4TSHR | |
| SCHEMBL983989 | 0.79 | LTA4H (0.38) | LTA4HRIPK1SLC6A2SLC6A4TSHR | |
| SCHEMBL3812990 | 0.79 | SLC6A2 (0.44) | LTA4HSLC6A2SLC6A4KDM4EALDH1A1 | |
| SCHEMBL455800 | 0.77 | GABRA1 (0.37) | HTTHPGDKDM4ENPSR1 | |
| SCHEMBL981916 | 0.76 | LTA4H (0.37) | LTA4HRIPK1SLC6A2SLC6A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114601930-A | Combination therapy of PD-1 signaling inhibitors | 国立大学法人京都大学 | 2022-06-10 | — | — | CN | claimed |
| CN-114404595-A | Combination therapy of PD-1 signaling inhibitors | 国立大学法人京都大学 | 2022-04-29 | — | — | CN | claimed |
| CN-114601930-A | Combination therapy of PD-1 signaling inhibitors | 国立大学法人京都大学 | 2022-06-10 | — | — | CN | disclosed |
| CN-114404595-A | Combination therapy of PD-1 signaling inhibitors | 国立大学法人京都大学 | 2022-04-29 | — | — | CN | disclosed |
| EP-2275406-B1 | PROCESS FOR PRODUCING ISOCYANATE | ASAHI CHEMICAL IND (JP) | 2018-11-28 | — | — | EP | disclosed |
| US-9233918-B2 | Isocyanate production process | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2016-01-12 | — | — | US | disclosed |
| US-20110092731-A1 | ISOCYANATE PRODUCTION PROCESS | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2011-04-21 | — | — | US | disclosed |
| EP-2275406-A1 | PROCESS FOR PRODUCING ISOCYANATE | Asahi Kasei Chemicals Corporation (JP) | 2011-01-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092731-A1 | ISOCYANATE PRODUCTION PROCESS | CPS1, PHGDH, APEH | LTA4H 1039/4885RIPK1 1613/4885SLC6A2 4820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.