Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 16/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR1E | P28566 | 1/20 | 0.41 |
| ▸ | HTR1F | P30939 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9800379 | 0.99 | HTR6 (0.54) | HTR6HTR2AHTR2CHTR2BHTR1D | |
| Hydrochloric Acid SCHEMBL9800411 | 0.98 | HTR6 (0.53) | HTR6HTR2AHTR2CHTR2BHTR1D | |
| SCHEMBL10691119 | 0.93 | HTR6 (0.53) | HTR6HTR2AHTR2CHTR2BHTR1D | |
| SCHEMBL917269 | 0.89 | HTR6 (0.56) | HTR6HTR2AHTR2CHTR2BHTR1D | |
| Hydrochloric Acid SCHEMBL9800412 | 0.89 | HTR2A (0.45) | HTR6HTR2AHTR2CHTR2BHTR1D | |
| SCHEMBL10695378 | 0.87 | HTR6 (0.58) | HTR6HTR1DHTR1ADRD2HTR1B | |
| SCHEMBL9800340 | 0.86 | HTR1D (0.54) | HTR6HTR2AHTR2CHTR1DHTR1A | |
| SCHEMBL10691162 | 0.86 | HTR6 (0.57) | HTR6HTR2AHTR2C | |
| SCHEMBL9800394 | 0.85 | ADRB2 (0.41) | HTR6HTR2AHTR1DADRB2 | |
| SCHEMBL9800377 | 0.84 | ADRB2 (0.46) | HTR6HTR2AHTR1DADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994483-A | 5-substituted-3-aminoalkyl indole derivatives for migraine | GLAXO GROUP LIMITED (GB) | 1991-02-19 | — | — | US | disclosed |
| US-4785016-A | VASOCONSTRICTION, MIGRAINES ALKANEAMINO, ALKANE SULFONAMIDE INDOLES | GLAXO GROUP LIMITED (GB) | 1988-11-15 | — | — | US | disclosed |
| CN-85104233-A | Chemical compound | — | 1987-01-07 | — | — | CN | disclosed |