Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.43 |
| ▸ | METAP2 | P50579 | 5/20 | 0.39 |
| ▸ | METAP1 | P53582 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9437467 | 1.00 | REN (0.43) | RENMETAP2METAP1TP53KDM4E | |
| SCHEMBL7436156 | 1.00 | REN (0.43) | RENMETAP2METAP1TP53KDM4E | |
| SCHEMBL1368930 | 1.00 | REN (0.43) | RENMETAP2METAP1TP53KDM4E | |
| SCHEMBL9676548 | 0.96 | REN (0.43) | RENMETAP2METAP1TP53KDM4E | |
| SCHEMBL8915949 | 0.94 | REN (0.42) | RENMETAP2METAP1TP53KDM4E | |
| SCHEMBL25348565 | 0.88 | METAP2 (0.41) | RENMETAP2METAP1TP53KDM4E | |
| SCHEMBL29100503 | 0.88 | METAP2 (0.41) | RENMETAP2METAP1TP53KDM4E | |
| SCHEMBL25348570 | 0.88 | METAP2 (0.41) | RENMETAP2METAP1TP53KDM4E | |
| Hydrochloric Acid SCHEMBL9848324 | 0.84 | REN (0.47) | RENMETAP2METAP1TP53KDM4E | |
| SCHEMBL8908821 | 0.83 | SHBG (0.35) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416373-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-03-13 | — | — | EP | disclosed |