Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.39 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9803095 | 0.98 | KCNH2 (0.44) | KDM4EALDH1A1TDP1KCNH2SMPD1 | |
| Oxalic Acid SCHEMBL9803165 | 0.90 | KDM4E (0.49) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL9803767 | 0.89 | NR2F2 (0.41) | KDM4EALDH1A1ABCB1CYP2D6MEN1 | |
| SCHEMBL9803091 | 0.87 | KDM4E (0.46) | KDM4ETDP1LMNAMAPTSMN1; SMN2 | |
| Oxalic Acid SCHEMBL9427500 | 0.84 | KDM4E (0.47) | KDM4EALDH1A1KCNH2SMPD1CYP3A4 | |
| SCHEMBL30357949 | 0.83 | GPBAR1 (0.42) | ALDH1A1TBXA2ROPRM1MAPTHTT | |
| SCHEMBL9803476 | 0.82 | OPRM1 (0.44) | KDM4EALDH1A1TDP1KCNH2CYP3A4 | |
| SCHEMBL7343184 | 0.82 | KCNH2 (0.49) | KDM4EALDH1A1KCNH2SMPD1ABCB1 | |
| Hydrochloric Acid SCHEMBL9803523 | 0.81 | OPRM1 (0.43) | KDM4EALDH1A1TDP1KCNH2CYP3A4 | |
| SCHEMBL9803513 | 0.81 | MAPK14 (0.44) | ALDH1A1KCNH2ABCB1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5075325-A | Cardiovascular disorders | SYNTHELABO (FR) | 1991-12-24 | — | — | US | disclosed |
| US-5001159-A | Hypotensive, antiulcer, antiischemic agents; migraines, asthma epilepsy, anticoagulants; cardiovasculat disorders | SYNTHELABO (FR) | 1991-03-19 | — | — | US | disclosed |