Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9803091 | 0.98 | KDM4E (0.46) | KDM4ETDP1ADRB2ADRB1ADRB3 | |
| Oxalic Acid SCHEMBL9803157 | 0.90 | KDM4E (0.47) | KDM4ETDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL9803763 | 0.89 | KDM4E (0.45) | KDM4EADRB2MEN1KMT2AALDH1A1 | |
| SCHEMBL9803095 | 0.87 | KCNH2 (0.44) | KDM4ETDP1MEN1KMT2AALDH1A1 | |
| Oxalic Acid SCHEMBL9427521 | 0.83 | KDM4E (0.41) | KDM4EADRB2ADRB1ADRB3ATM | |
| SCHEMBL9427352 | 0.81 | NPC1 (0.42) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL9803513 | 0.80 | MAPK14 (0.44) | ADRB1ALDH1A1MAPTMAPK14 | |
| SCHEMBL9803476 | 0.79 | OPRM1 (0.44) | KDM4ETDP1ADRB1ALDH1A1MAPK14 | |
| Hydrochloric Acid SCHEMBL9803523 | 0.79 | OPRM1 (0.43) | KDM4ETDP1ADRB1MEN1KMT2A | |
| SCHEMBL9803767 | 0.78 | NR2F2 (0.41) | KDM4EMEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5075325-A | Cardiovascular disorders | SYNTHELABO (FR) | 1991-12-24 | — | — | US | disclosed |
| US-5001159-A | Hypotensive, antiulcer, antiischemic agents; migraines, asthma epilepsy, anticoagulants; cardiovasculat disorders | SYNTHELABO (FR) | 1991-03-19 | — | — | US | disclosed |