Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19974826 | 0.89 | CYP3A4 (0.44) | OPRM1L3MBTL1HTTALDH1A1MAPT | |
| SCHEMBL19974843 | 0.73 | LMNA (0.46) | OPRM1L3MBTL1ALDH1A1MAPTMEN1 | |
| SCHEMBL19974745 | 0.72 | LMNA (0.45) | OPRM1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9803161 | 0.71 | GAA (0.42) | OPRM1HTTMAPTMEN1KMT2A | |
| SCHEMBL9802824 | 0.70 | ALDH1A1 (0.43) | L3MBTL1HTTCACNA1GALDH1A1MAPT | |
| SCHEMBL9802481 | 0.70 | ALDH1A1 (0.43) | L3MBTL1HTTCACNA1GALDH1A1MAPT | |
| SCHEMBL19838774 | 0.69 | OPRM1 (0.43) | OPRM1L3MBTL1HTTALDH1A1MAPT | |
| SCHEMBL6997222 | 0.67 | GAA (0.58) | ALDH1A1MEN1KMT2AKDM4ERECQL | |
| SCHEMBL19850659 | 0.67 | OPRM1 (0.41) | OPRM1L3MBTL1ALDH1A1MAPTKDM4E | |
| SCHEMBL19838521 | 0.66 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2ALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049577-A | 2-pyrrolidone substituted dihydroxy alkanoic, alkenoic and alkynoic acids, compositions and HMG-CoA reductase inhibition therewith | E. R. SQUIBB & SONS, INC. (US) | 1991-09-17 | — | — | US | disclosed |