Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6608244 | 0.94 | LTA4H (0.44) | LTA4HMAPTNPC1RAB9AKCNH2 | |
| SCHEMBL18013086 | 0.83 | MAPT (0.53) | LTA4HMAPTKCNH2TDP1L3MBTL1 | |
| SCHEMBL16726530 | 0.81 | LOXL2 (0.53) | LTA4HMAPTNPC1RAB9AKCNH2 | |
| SCHEMBL13481254 | 0.81 | NPC1 (0.50) | LTA4HMAPTNPC1RAB9AKCNH2 | |
| SCHEMBL10642084 | 0.81 | ALDH1A1 (0.55) | LTA4HMAPTNPC1RAB9ATDP1 | |
| SCHEMBL11547369 | 0.80 | RAB9A (0.43) | LTA4HMAPTNPC1RAB9AKCNH2 | |
| SCHEMBL9618163 | 0.78 | CHRNB4 (0.49) | LTA4HMAPTNPC1RAB9AKCNH2 | |
| SCHEMBL9165943 | 0.77 | ELANE (0.61) | LTA4HMAPTNPC1RAB9ATP53 | |
| SCHEMBL2539650 | 0.75 | MEN1 (0.50) | MAPTNPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL10489374 | 0.75 | RAB9A (0.45) | MAPTNPC1RAB9AL3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5075300-A | Hypoglycemic and antilipemic agents | BEECHAM GROUP P.L.C. (GB) | 1991-12-24 | — | — | US | disclosed |
| EP-0356214-A2 | Thiazolidine dione derivatives | BEECHAM GROUP PLC (GB) | 1990-02-28 | — | — | EP | disclosed |