Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CTSC | P53634 | 5/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | P4HB | P07237 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | PIEZO1 | Q92508 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9804762 | 0.87 | CTSC (0.39) | VNN1CTSCGRIN2BGRIN1TAAR1 | |
| SCHEMBL9804841 | 0.82 | CYP3A4 (0.38) | KDM4EPOLB | |
| SCHEMBL9804735 | 0.82 | CYP19A1 (0.42) | VNN1GAACTSCGRIN2BGRIN1 | |
| SCHEMBL9557231 | 0.78 | CYP19A1 (0.39) | TAAR1MIFMAOBKDM4E | |
| SCHEMBL9804823 | 0.77 | EBP (0.39) | VNN1 | |
| SCHEMBL9804718 | 0.75 | PIEZO1 (0.40) | VNN1GRIN2BGRIN1NR3C2MAOB | |
| SCHEMBL9804794 | 0.74 | CYP19A1 (0.37) | KDM4E | |
| SCHEMBL9804916 | 0.73 | CYP19A1 (0.38) | VNN1GAAGRIN2BGRIN1KDM4E | |
| SCHEMBL9557665 | 0.72 | TAAR1 (0.48) | GAAGRIN2BGRIN1TAAR1MIF | |
| SCHEMBL10371526 | 0.72 | CYP19A1 (0.46) | VNN1CTSCGRIN2BTAAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276920-B1 | (2-CYANO-2-(PHENYL OR NAPHTHYL)-2-SUBSTITUTED-ETHYL) PYRAZINES, PYRIMIDINES AND PYRIDAZINES | ROHM AND HAAS COMPANY (US) | 1991-04-03 | — | — | EP | disclosed |
| EP-0276920-A1 | (2-Cyano-2-(phenyl or naphthyl)-2-substituted-ethyl) pyrazines, pyrimidines and pyridazines | ROHM AND HAAS COMPANY (US) | 1988-08-03 | — | — | EP | disclosed |