Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.60 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.60 |
| ▸ | HCAR2 | Q8TDS4 | 7/20 | 0.52 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.41 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL9805373 | 1.00 | TSHR (0.60) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL28105558 | 0.88 | TSHR (0.53) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL4237189 | 0.86 | TSHR (0.69) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL4240001 | 0.86 | TSHR (0.69) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL15794260 | 0.86 | TSHR (0.69) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL4237193 | 0.86 | TSHR (0.69) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL19691762 | 0.86 | TSHR (0.69) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Crotonic Acid SCHEMBL28103163 | 0.85 | — | — | |
| Fumaric Acid SCHEMBL7836361 | 0.83 | TSHR (0.64) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL10994264 | 0.83 | TSHR (0.64) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5061667-A | REDUCED POWDERING OF POLYMER DURING POLYMERIZATION | TOG NENRYO KOGYO KK (TONEN CORPORATION) (JP) | 1991-10-29 | — | — | US | disclosed |
| EP-0173470-B1 | CATALYST COMPONENT FOR POLYMERIZATION OF OLEFINS | Tonen Corporation (JP) | 1991-03-20 | — | — | EP | disclosed |
| EP-0173472-B1 | CATALYST COMPONENT FOR POLYMERIZATION OF OLEFINS | Tonen Corporation (JP) | 1990-12-19 | — | — | EP | disclosed |
| EP-0264169-B1 | PROCESS FOR PRODUCING ETHYLENE-PROPYLENE COPOLYMER RUBBER | Tonen Corporation (JP) | 1990-11-22 | — | — | EP | disclosed |
| US-4959427-A | COORDINATION CATALYST CONTAINING DIALKYLMAGNESIUM, STEREOREGULAR POLYMERIZATION OF PROPYLENE | TOA NENRYO KOGYO, K.K. (JP) | 1990-09-25 | — | — | US | disclosed |
| EP-0147053-B1 | A CATALYST AND A PROCESS FOR POLYMERIZATION OF OLEFINS | Tonen Corporation (JP) | 1990-09-05 | — | — | EP | disclosed |
| US-4950630-A | MAGNESIUM TITANIUM CHLORIDE; MAGNESIUM AND HALOGENATED HYDROCARBON AND ALCOHOL; ALKOXY COMPOUND; ELECTRON DONOR AND TITANIUM COMPONENT | TOA NENRYO KOGYO, K.K. (JP) | 1990-08-21 | — | — | US | disclosed |
| US-4942148-A | COORDINATION CATALYLTS OF METAL OXIDE, ORGANOMAGNESIUM COMPOUNDS, AN ORGANOALUMINUM COMPOUND, A TITANIUM COMPOUND AND ELECTRON DONOR COMPOUND | TOA NENRYO KOGYO, K.K. (JP) | 1990-07-17 | — | — | US | disclosed |
| EP-0208524-B1 | CATALYST COMPONENT FOR OLEFIN POLYMERIZATION | Tonen Corporation (JP) | 1990-05-16 | — | — | EP | disclosed |
| EP-0193281-B1 | CATALYST COMPONENT FOR OLEFIN POLYMERIZATION | TOA NENRYO KOGYO KABUSHIKI KAISHA (JP) | 1990-04-11 | — | — | EP | disclosed |
| EP-0193281-A2 | Catalyst component for olefin polymerization | TOA NENRYO KOGYO KABUSHIKI KAISHA (JP) | 1986-09-03 | — | — | EP | disclosed |
| EP-0173472-A2 | Catalyst component for polymerization of olefins | Tonen Corporation (JP) | 1986-03-05 | — | — | EP | disclosed |
| EP-0173470-A2 | Catalyst component for polymerization of olefins | Tonen Corporation (JP) | 1986-03-05 | — | — | EP | disclosed |
| EP-0171155-A1 | Catalyst component for polymerization of olefins | Tonen Corporation (JP) | 1986-02-12 | — | — | EP | disclosed |
| EP-0171200-A2 | Catalyst component for polymerization of olefins | TOA NENRYO KOGYO KABUSHIKI KAISHA (JP) | 1986-02-12 | — | — | EP | disclosed |
| US-4565798-A | COORDINATION CATALYSTS, TITANIUM, MAGNESIUM, SILICON COMPOUND | TOA NENRYO KOGYO KABUSHIKI KAISHA (JP) | 1986-01-21 | — | — | US | disclosed |
| EP-0157472-A1 | Process for polymerization of olefins | TOA NENRYO KOGYO KABUSHIKI KAISHA (JP) | 1985-10-09 | — | — | EP | disclosed |
| EP-0156512-A1 | Process for preparing catalyst component for polymerization of olefins | TOA NENRYO KOGYO KABUSHIKI KAISHA (JP) | 1985-10-02 | — | — | EP | disclosed |
| EP-0147053-A1 | A catalyst and a process for polymerization of olefins | Tonen Corporation (JP) | 1985-07-03 | — | — | EP | disclosed |
| EP-0145368-A2 | Process for producing propylene block copolymers | TOA NENRYO KOGYO KABUSHIKI KAISHA (JP) | 1985-06-19 | — | — | EP | disclosed |