SCHEMBL9805484

SCHEMBL9805484

CC1=C(C(=O)O)C(c2cccc([N+](=O)[O-])c2)N/C(=N/C#N)N1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.56
L3MBTL1 Q9Y468 1/20 0.56
LMNA P02545 2/20 0.55
GUSB P08236 1/20 0.52
ADORA3 P0DMS8 2/20 0.47
NR1I2 O75469 1/20 0.47
NR3C1 P04150 1/20 0.47
ABCB1 P08183 1/20 0.47
TBXA2R P21731 1/20 0.47
AGTR1 P30556 1/20 0.47
CCKBR P32239 1/20 0.47
PTGS2 P35354 1/20 0.47
PDE4D Q08499 1/20 0.47
SCN5A Q14524 1/20 0.47
SLC29A1 Q99808 1/20 0.47
CACNA1F O60840 2/20 0.47
CACNA1D Q01668 2/20 0.47
CACNA1S Q13698 2/20 0.47
CACNA1C Q13936 2/20 0.47
PDE1C Q14123 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9805492 1.00 ALDH1A1 (0.56) ALDH1A1L3MBTL1LMNAGUSBADORA3
SCHEMBL9805503 0.86 ALDH1A1 (0.59) ALDH1A1L3MBTL1LMNAGUSBADORA3
SCHEMBL9805495 0.86 ALDH1A1 (0.59) ALDH1A1L3MBTL1LMNAGUSBADORA3
SCHEMBL8108247 0.82 ALDH1A1 (0.63) ALDH1A1L3MBTL1LMNAGUSBADORA3
SCHEMBL19732964 0.82 ALDH1A1 (0.63) ALDH1A1L3MBTL1LMNAGUSBADORA3
SCHEMBL7265815 0.81 ALDH1A1 (0.83) ALDH1A1L3MBTL1LMNAGUSBADORA3
SCHEMBL9814256 0.80 ALDH1A1 (0.62) ALDH1A1L3MBTL1LMNAGUSBADORA3
SCHEMBL9805543 0.78 CACNA1F (0.50) ALDH1A1L3MBTL1ADORA3CACNA1FCACNA1D
SCHEMBL9805535 0.78 CACNA1F (0.50) ALDH1A1L3MBTL1ADORA3CACNA1FCACNA1D
SCHEMBL3940339 0.75 CACNA1F (0.71) LMNAADORA3CACNA1FCACNA1DCACNA1S

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0234830-B1 2-(SUBSTITUTED IMINO)-6-ARYL-3,6-DIHYDRO-4-SUBSTITUTED-1,5(2H)-PYRIMIDINECARBOXYLIC ACIDS AND ANALOGS E.R. Squibb & Sons, Inc. (US) 1991-04-24 EP disclosed
EP-0234830-A1 2-(Substituted imino)-6-aryl-3,6-dihydro-4-substituted-1,5(2H)-pyrimidinecarboxylic acids and analogs E.R. Squibb & Sons, Inc. (US) 1987-09-02 EP disclosed
US-4689414-A 2-(substituted imino)-6-aryl-3,6-dihydro-4-substituted-1,5(2H)-pyrimidinecarboxylic acids and analogs E. R. SQUIBB & SONS, INC. (US) 1987-08-25 US disclosed