SCHEMBL9805503

SCHEMBL9805503

CC1=C(C(=O)O)C(c2cccc([N+](=O)[O-])c2)NC(=N[N+](=O)[O-])N1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.59
L3MBTL1 Q9Y468 1/20 0.59
LMNA P02545 2/20 0.58
GUSB P08236 1/20 0.54
CACNA1C Q13936 4/20 0.49
CACNA1F O60840 3/20 0.49
CACNA1D Q01668 3/20 0.49
CACNA1S Q13698 3/20 0.49
ADORA3 P0DMS8 1/20 0.49
PDE1C Q14123 1/20 0.47
CACNA1B Q00975 1/20 0.47
HIF1A Q16665 3/20 0.46
MEN1 O00255 2/20 0.46
CYP1A2 P05177 2/20 0.46
CYP3A4 P08684 2/20 0.46
CYP2C9 P11712 2/20 0.46
CYP2C19 P33261 2/20 0.46
KMT2A Q03164 2/20 0.46
MAPT P10636 2/20 0.46
POLB P06746 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9805495 1.00 ALDH1A1 (0.59) ALDH1A1L3MBTL1LMNAGUSBCACNA1C
SCHEMBL9805492 0.86 ALDH1A1 (0.56) ALDH1A1L3MBTL1LMNAGUSBCACNA1C
SCHEMBL9805484 0.86 ALDH1A1 (0.56) ALDH1A1L3MBTL1LMNAGUSBCACNA1C
SCHEMBL8108247 0.85 ALDH1A1 (0.63) ALDH1A1L3MBTL1LMNAGUSBCACNA1C
SCHEMBL19732964 0.85 ALDH1A1 (0.63) ALDH1A1L3MBTL1LMNAGUSBCACNA1C
SCHEMBL7265815 0.84 ALDH1A1 (0.83) ALDH1A1L3MBTL1LMNAGUSBCACNA1C
SCHEMBL9814256 0.83 ALDH1A1 (0.62) ALDH1A1L3MBTL1LMNAGUSBCACNA1C
SCHEMBL3940339 0.78 CACNA1F (0.71) LMNACACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL3032197 0.78 CACNA1F (0.71) LMNACACNA1CCACNA1FCACNA1DCACNA1S
Hydrochloric Acid SCHEMBL9374064 0.77 CACNA1F (0.70) LMNACACNA1CCACNA1FCACNA1DCACNA1S

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0234830-B1 2-(SUBSTITUTED IMINO)-6-ARYL-3,6-DIHYDRO-4-SUBSTITUTED-1,5(2H)-PYRIMIDINECARBOXYLIC ACIDS AND ANALOGS E.R. Squibb & Sons, Inc. (US) 1991-04-24 EP disclosed
EP-0234830-A1 2-(Substituted imino)-6-aryl-3,6-dihydro-4-substituted-1,5(2H)-pyrimidinecarboxylic acids and analogs E.R. Squibb & Sons, Inc. (US) 1987-09-02 EP disclosed
US-4689414-A 2-(substituted imino)-6-aryl-3,6-dihydro-4-substituted-1,5(2H)-pyrimidinecarboxylic acids and analogs E. R. SQUIBB & SONS, INC. (US) 1987-08-25 US disclosed