SCHEMBL9814256

SCHEMBL9814256

CC1=C(C(=O)O)C(c2cccc([N+](=O)[O-])c2)Nc2ccccc2N1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.62
LMNA P02545 2/20 0.62
L3MBTL1 Q9Y468 1/20 0.60
GUSB P08236 1/20 0.55
CACNA1C Q13936 3/20 0.53
PDE1C Q14123 1/20 0.51
CACNA1F O60840 2/20 0.50
CACNA1D Q01668 2/20 0.50
CACNA1S Q13698 2/20 0.50
ADORA3 P0DMS8 1/20 0.50
CACNA1B Q00975 1/20 0.50
ATM Q13315 1/20 0.48
HIF1A Q16665 3/20 0.47
MEN1 O00255 2/20 0.47
CYP1A2 P05177 2/20 0.47
CYP3A4 P08684 2/20 0.47
CYP2C9 P11712 2/20 0.47
CYP2C19 P33261 2/20 0.47
KMT2A Q03164 2/20 0.47
MAPT P10636 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8108247 0.86 ALDH1A1 (0.63) ALDH1A1LMNAL3MBTL1GUSBCACNA1C
SCHEMBL19732964 0.86 ALDH1A1 (0.63) ALDH1A1LMNAL3MBTL1GUSBCACNA1C
SCHEMBL7265815 0.85 ALDH1A1 (0.83) ALDH1A1LMNAL3MBTL1GUSBCACNA1C
SCHEMBL9805503 0.83 ALDH1A1 (0.59) ALDH1A1LMNAL3MBTL1GUSBCACNA1C
SCHEMBL9805495 0.83 ALDH1A1 (0.59) ALDH1A1LMNAL3MBTL1GUSBCACNA1C
SCHEMBL9805484 0.80 ALDH1A1 (0.56) ALDH1A1LMNAL3MBTL1GUSBCACNA1C
SCHEMBL9805492 0.80 ALDH1A1 (0.56) ALDH1A1LMNAL3MBTL1GUSBCACNA1C
SCHEMBL3032197 0.79 CACNA1F (0.71) LMNACACNA1CPDE1CCACNA1FCACNA1D
SCHEMBL3940339 0.79 CACNA1F (0.71) LMNACACNA1CPDE1CCACNA1FCACNA1D
SCHEMBL10743987 0.79 CACNA1C (0.79) ALDH1A1LMNAL3MBTL1GUSBCACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0253178-B1 SUBSTITUTED 1,5-BENZODIAZEPINE COMPOUNDS E.R. Squibb & Sons, Inc. (US) 1991-08-14 EP disclosed
EP-0253178-A1 Substituted 1,5-benzodiazepine compounds E.R. Squibb & Sons, Inc. (US) 1988-01-20 EP disclosed
US-4650797-A HYPOTENSIVES E. R. SQUIBB & SONS, INC. (US) 1987-03-17 US disclosed
US-4647561-A HYPOTENSIVE AGENTS E. R. SQUIBB & SONS, INC. (US) 1987-03-03 US disclosed
EP-0211429-A1 1,5-Benzodiazepine compounds E.R. Squibb & Sons, Inc. (US) 1987-02-25 EP disclosed