Prednisolone Acetate

SCHEMBL9806568

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nearest known ligand 0.93

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Prednisolone Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	7/20	0.85

▸	HIF1A	Q16665	6/20	0.93

▸	PGR	P06401	6/20	0.93

▸	HSD17B10	Q99714	5/20	0.85

▸	CYP3A4	P08684	4/20	0.85

▸	AR	P10275	3/20	0.85

▸	SERPINA6	P08185	2/20	0.85

▸	ABCB11	O95342	2/20	0.85

▸	TNF	P01375	1/20	0.85

▸	IL6	P05231	1/20	0.85

▸	NR3C2	P08235	1/20	0.85

▸	GLUL	P15104	1/20	0.85

▸	ADAM17	P78536	1/20	0.85

▸	GPBAR1	Q8TDU6	1/20	0.85

▸	CYP2C19	P33261	1/20	0.85

▸	LMNA	P02545	3/20	0.73

▸	F2	P00734	1/20	0.69

▸	KMT2A	Q03164	2/20	0.67

▸	CHRM1	P11229	1/20	0.67

▸	ALDH1A1	P00352	1/20	0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Prednisolone Acetate SCHEMBL9806574	1.00	HIF1A (0.93)	HIF1APGRNR3C1HSD17B10CYP3A4
Prednisolone Acetate SCHEMBL7999	0.97	HIF1A (1.00)	HIF1APGRNR3C1HSD17B10CYP3A4
Prednisolone Acetate SCHEMBL13044467	0.97	HIF1A (1.00)	HIF1APGRNR3C1HSD17B10CYP3A4
Prednisolone Acetate SCHEMBL8000	0.97	HIF1A (1.00)	HIF1APGRNR3C1HSD17B10CYP3A4
Prednisolone Acetate SCHEMBL10118889	0.97	HIF1A (1.00)	HIF1APGRNR3C1HSD17B10CYP3A4
Prednisolone SCHEMBL8428383	0.92	NR3C1 (0.90)	HIF1APGRNR3C1HSD17B10CYP3A4
Prednisolone SCHEMBL35448	0.92	NR3C1 (0.90)	HIF1APGRNR3C1HSD17B10CYP3A4
Prednisolone SCHEMBL7060461	0.92	NR3C1 (0.96)	HIF1APGRNR3C1HSD17B10CYP3A4
Prednisolone SCHEMBL23863778	0.92	NR3C1 (1.00)	HIF1APGRNR3C1HSD17B10CYP3A4
Prednisolone SCHEMBL2737385	0.92	NR3C1 (1.00)	HIF1APGRNR3C1HSD17B10CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0422140-A1	THYROLEBERIN AS IMMUNOMODULATOR AND LIPID REGULATOR	PIERPAOLI, Walter (CH)	1991-04-17	—	—	EP	disclosed
WO-1990008583-A2	THYROLEBERIN AS IMMUNOMODULATOR AND LIPID REGULATOR	PIERPAOLI WALTER (CH)	1990-08-09	—	—	WO	disclosed