Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prednisolone Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 0.85 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.93 |
| ▸ | PGR | P06401 | 6/20 | 0.93 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.85 |
| ▸ | AR | P10275 | 3/20 | 0.85 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.85 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.85 |
| ▸ | TNF | P01375 | 1/20 | 0.85 |
| ▸ | IL6 | P05231 | 1/20 | 0.85 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.85 |
| ▸ | GLUL | P15104 | 1/20 | 0.85 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.85 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.85 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.85 |
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | F2 | P00734 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prednisolone Acetate SCHEMBL9806568 | 1.00 | HIF1A (0.93) | HIF1APGRNR3C1HSD17B10CYP3A4 | |
| Prednisolone Acetate SCHEMBL7999 | 0.97 | HIF1A (1.00) | HIF1APGRNR3C1HSD17B10CYP3A4 | |
| Prednisolone Acetate SCHEMBL13044467 | 0.97 | HIF1A (1.00) | HIF1APGRNR3C1HSD17B10CYP3A4 | |
| Prednisolone Acetate SCHEMBL8000 | 0.97 | HIF1A (1.00) | HIF1APGRNR3C1HSD17B10CYP3A4 | |
| Prednisolone Acetate SCHEMBL10118889 | 0.97 | HIF1A (1.00) | HIF1APGRNR3C1HSD17B10CYP3A4 | |
| Prednisolone SCHEMBL8428383 | 0.92 | NR3C1 (0.90) | HIF1APGRNR3C1HSD17B10CYP3A4 | |
| Prednisolone SCHEMBL35448 | 0.92 | NR3C1 (0.90) | HIF1APGRNR3C1HSD17B10CYP3A4 | |
| Prednisolone SCHEMBL7060461 | 0.92 | NR3C1 (0.96) | HIF1APGRNR3C1HSD17B10CYP3A4 | |
| Prednisolone SCHEMBL23863778 | 0.92 | NR3C1 (1.00) | HIF1APGRNR3C1HSD17B10CYP3A4 | |
| Prednisolone SCHEMBL2737385 | 0.92 | NR3C1 (1.00) | HIF1APGRNR3C1HSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422140-A1 | THYROLEBERIN AS IMMUNOMODULATOR AND LIPID REGULATOR | PIERPAOLI, Walter (CH) | 1991-04-17 | — | — | EP | disclosed |
| WO-1990008583-A2 | THYROLEBERIN AS IMMUNOMODULATOR AND LIPID REGULATOR | PIERPAOLI WALTER (CH) | 1990-08-09 | — | — | WO | disclosed |