Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PTPRB | P23467 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19857113 | 0.87 | MEN1 (0.55) | MRGPRX4MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL7808144 | 0.85 | HPGD (0.64) | MRGPRX4MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL9031774 | 0.78 | ALDH1A1 (0.53) | MEN1KMT2ASMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL3224230 | 0.77 | LTA4H (0.76) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL10735781 | 0.77 | MRGPRX4 (0.45) | MRGPRX4MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL9808278 | 0.76 | ALDH1A1 (0.55) | KMT2ASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL7227329 | 0.76 | HPGD (0.49) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL10905417 | 0.76 | MRGPRX4 (0.44) | MRGPRX4MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL10903897 | 0.76 | L3MBTL1 (0.55) | MRGPRX4MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8057855 | 0.76 | MEN1 (0.55) | MRGPRX4MEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026853-A | Sleep and cardiovascular disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-06-25 | — | — | US | disclosed |
| US-4968684-A | N-ARYL-PIPERAZINEALKANAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-11-06 | — | — | US | disclosed |
| US-4880808-A | SEDATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-11-14 | — | — | US | disclosed |