Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.46 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10969876 | 0.75 | ALDH1A1 (0.47) | ALDH1A1GAAMAPTSLC5A1SLC5A2 | |
| SCHEMBL11526781 | 0.74 | NPC1 (0.56) | ALDH1A1GAAMAPTSLC5A1SLC5A2 | |
| SCHEMBL9808448 | 0.74 | S1PR1 (0.43) | ALDH1A1NPC1RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL10565203 | 0.73 | S1PR1 (0.42) | ALDH1A1GAAMAPTNPC1RAB9A | |
| SCHEMBL1844262 | 0.72 | SLC5A1 (0.58) | ALDH1A1GAAMAPTSLC5A1SLC5A2 | |
| SCHEMBL10971703 | 0.72 | GAA (0.54) | ALDH1A1GAAMAPTSLC5A1SLC5A2 | |
| SCHEMBL11239913 | 0.72 | SLC5A1 (0.54) | ALDH1A1GAAMAPTSLC5A1SLC5A2 | |
| SCHEMBL3865201 | 0.72 | DAO (0.51) | ALDH1A1GAAMAPTSLC5A1SLC5A2 | |
| SCHEMBL27889179 | 0.71 | RECQL (0.62) | ALDH1A1KEAP1P2RX7CYP1A1CYP1B1 | |
| SCHEMBL12330301 | 0.68 | NPC1 (0.70) | ALDH1A1MAPTKEAP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266336-B1 | 1-[3-(2-Dialkylaminoethoxy)-2-thienyl]-3-phenyl-1-propanones and their acid addition salts, process for their preparation and pharmaceutical compositions containing them | Binder, Dieter, Prof. Dr. (AT) | 1991-05-15 | — | — | EP | disclosed |
| US-4814330-A | CARDIOVASCULAR DISORDERS | BINDER DIETER (AT) | 1989-03-21 | — | — | US | disclosed |
| EP-0266336-A1 | 1-[3-(2-Dialkylaminoethoxy)-2-thienyl]-3-phenyl-1-propanones and their acid addition salts, process for their preparation and pharmaceutical compositions containing them | Binder, Dieter, Prof. Dr. (AT) | 1988-05-04 | — | — | EP | disclosed |
| EP-0233173-A1 | 1-[3-(2-Hydroxy-3-alkylamino-propoxy)-2-thienyl]-3-phenyl-1-propanones and their acid addition salts, process for their preparation and pharmaceutical compositions containing them | Laevosan-Gesellschaft m.b.H. (AT) | 1987-08-19 | — | — | EP | disclosed |
| EP-0053603-B1 | 1-(3-(2-HYDROXY-3-ALKYLAMINOPROPOXY)-2-THIENYL)-3-PHENYL-1 PROPANONES AND THEIR ACID ADDITION SALTS, AND PROCESS FOR THEIR PREPARATION | Laevosan-Gesellschaft m.b.H. & Co KG (AT) | 1985-04-03 | — | — | EP | disclosed |
| US-4352819-A | ANTIARRHYTHMIA AGENTS | LAEVOSAN-GESELLSCHAFT MBH & CO. KG (AT) | 1982-10-05 | — | — | US | disclosed |