Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM6B | O15054 | 2/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.45 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697917 | 0.98 | ALDH1A1 (0.63) | ALDH1A1HSD17B10HPGDKDM4CKDM4E | |
| Hydrochloric Acid SCHEMBL516167 | 0.92 | ALDH1A1 (0.63) | ALDH1A1HSD17B10HPGDKDM4CKDM4E | |
| SCHEMBL9809381 | 0.86 | ALDH1A1 (0.69) | ALDH1A1HSD17B10HPGDKDM4CKDM4E | |
| SCHEMBL8689214 | 0.86 | ALDH1A1 (0.79) | ALDH1A1HSD17B10HPGDKDM4CKDM4E | |
| SCHEMBL5694119 | 0.84 | PLK1 (0.66) | ALDH1A1HSD17B10HPGDKDM4CKDM4E | |
| SCHEMBL3475665 | 0.84 | PLK1 (0.66) | ALDH1A1HSD17B10HPGDKDM4CKDM4E | |
| SCHEMBL11432358 | 0.84 | PLK1 (0.66) | ALDH1A1HSD17B10HPGDKDM4CKDM4E | |
| SCHEMBL5272720 | 0.84 | PLK1 (0.66) | ALDH1A1HSD17B10HPGDKDM4CKDM4E | |
| SCHEMBL11443814 | 0.84 | PLK1 (0.66) | ALDH1A1HSD17B10HPGDKDM4CKDM4E | |
| SCHEMBL5518973 | 0.84 | ALDH1A1 (0.76) | ALDH1A1HSD17B10HPGDKDM4CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0283563-B1 | NOVEL DERIVATIVES | BEECHAM GROUP PLC (GB) | 1991-05-29 | — | — | EP | disclosed |
| EP-0155388-B1 | ENZYME-PROTEIN CONJUGATE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL USE THEREOF | BEECHAM GROUP PLC (GB) | 1989-03-29 | — | — | EP | disclosed |
| EP-0283563-A2 | Novel derivatives | BEECHAM GROUP PLC (GB) | 1988-09-28 | — | — | EP | disclosed |
| US-4741903-A | Novel enzyne derivatives | BEECHAM GROUP P.L.C. (GB) | 1988-05-03 | — | — | US | disclosed |
| US-4730050-A | Novel enzyme derivatives | BEECHAM GROUP P.L.C. (GB) | 1988-03-08 | — | — | US | disclosed |
| US-4600580-A | Novel enzyme derivatives | BEECHAM GROUP P.L.C. (GB) | 1986-07-15 | — | — | US | disclosed |
| EP-0184363-A2 | Enzyme conjugates and their therapeutical use | BEECHAM GROUP PLC (GB) | 1986-06-11 | — | — | EP | disclosed |
| EP-0155388-A2 | Enzyme-protein conjugate, process for its preparation and pharmaceutical use thereof | BEECHAM GROUP PLC (GB) | 1985-09-25 | — | — | EP | disclosed |