Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PEPD | P12955 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4696811 | 0.83 | HSD17B10 (0.47) | HPGDMEN1KMT2AHSD17B10NPC1 | |
| SCHEMBL10964498 | 0.81 | HPGD (0.34) | HPGDCYP1A2MEN1KMT2ACYP2C9 | |
| SCHEMBL7063953 | 0.79 | DDX3X (0.36) | KIF11MEN1KMT2APEPDNPC1 | |
| SCHEMBL2895076 | 0.77 | PARP1 (0.41) | NR3C2PARP1MEN1KMT2ANPC1 | |
| SCHEMBL7701540 | 0.77 | IKBKB (0.40) | HPGDNR3C2MEN1KMT2AHSD17B10 | |
| SCHEMBL28133756 | 0.75 | CA12 (0.39) | HPGD | |
| SCHEMBL6337960 | 0.74 | MGLL (0.42) | KIF11CYP1A2 | |
| SCHEMBL27924027 | 0.74 | KCNMA1 (0.55) | MEN1KMT2ANPC1 | |
| SCHEMBL27906119 | 0.74 | KCNK3 (0.52) | HPGDCYP1A2MEN1KMT2ACYP2C9 | |
| SCHEMBL11577666 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255098-B1 | Novel 8-(lower alkyl) bicyclo [4.2.0] octane derivatives with valuable therapeutic properties | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| EP-0196617-B1 | [4.2.0]bicyclooctane derivatives, process for their preparation and pharmaceutical compositions containing same | SYNTEX (U.S.A.) INC. (US) | 1989-05-31 | — | — | EP | disclosed |
| EP-0255098-A1 | Novel 8-(lower alkyl) bicyclo [4.2.0] octane derivatives with valuable therapeutic properties | SYNTEX (U.S.A.) INC. (US) | 1988-02-03 | — | — | EP | disclosed |
| EP-0237695-A2 | 1,4-Dihydropyridines | MERCK PATENT GmbH (DE) | 1987-09-23 | — | — | EP | disclosed |
| US-4678805-A | Novel 8-(lower alkyl)bicyclo[4.2.0]octane derivatives with valuable therapeutic properties | SYNTEX (U.S.A.) INC. (US) | 1987-07-07 | — | — | US | disclosed |
| EP-0196617-A1 | [4.2.0]bicyclooctane derivatives, process for their preparation and pharmaceutical compositions containing same | SYNTEX (U.S.A.) INC. (US) | 1986-10-08 | — | — | EP | disclosed |
| US-4608388-A | Novel [4,2,0]bicyclooctane derivatives with valuable therapeutic properties | SYNTEX (U.S.A.) INC. (US) | 1986-08-26 | — | — | US | disclosed |