Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6937148 | 0.85 | MAOA (0.40) | PLK1ALDH1A1KMT2AMEN1GAA | |
| SCHEMBL9809965 | 0.77 | KIF11 (0.42) | ALDH1A1KMT2AMEN1HSD17B10HPGD | |
| SCHEMBL7063953 | 0.75 | DDX3X (0.36) | IKBKBALDH1A1KMT2AMEN1GAA | |
| SCHEMBL2895076 | 0.73 | PARP1 (0.41) | IKBKBALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6337960 | 0.70 | MGLL (0.42) | IKBKBGAAMAPTHDAC3HDAC1 | |
| SCHEMBL7495051 | 0.69 | LOXL2 (0.40) | ALDH1A1KMT2AGAAMAPTHSD17B10 | |
| SCHEMBL5031452 | 0.69 | SIGMAR1 (0.60) | ALDH1A1KMT2AMEN1GAAMAPT | |
| SCHEMBL6610027 | 0.68 | SMN1; SMN2 (0.38) | IKBKBALDH1A1KMT2AMAPTSIGMAR1 | |
| SCHEMBL7491203 | 0.68 | BCL2 (0.45) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8884369 | 0.68 | SIGMAR1 (0.61) | ALDH1A1KMT2AMEN1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037871-B1 | NOVEL ANTIARRHYTHMIC COMPOUNDS | GYOGYSZERKUTATO INTEZET (HU) | 2002-07-03 | — | — | EP | disclosed |
| US-6265445-B1 | CARDIOVASCULAR DISORDERS | GYOGYSZERKUTATO INTEZET KFT (HU) | 2001-07-24 | — | — | US | disclosed |
| US-4766213-A | 1,4-dihydropyridines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1988-08-23 | — | — | US | disclosed |
| EP-0237695-A2 | 1,4-Dihydropyridines | MERCK PATENT GmbH (DE) | 1987-09-23 | — | — | EP | disclosed |