Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28381067 | 0.82 | MEN1 (0.45) | SMN1; SMN2MEN1NPC1KMT2ACYP4F2 | |
| SCHEMBL7898631 | 0.78 | MEN1 (0.48) | SMN1; SMN2MEN1NPC1KMT2AALDH1A1 | |
| SCHEMBL27567099 | 0.77 | SMN1; SMN2 (0.40) | SMN1; SMN2MEN1NPC1KMT2ACYP4F2 | |
| SCHEMBL8657199 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2MEN1NPC1KMT2ACYP4F2 | |
| SCHEMBL28739946 | 0.75 | NR4A2 (0.34) | ALDH1A1TSHRTDP1 | |
| SCHEMBL7890967 | 0.75 | MEN1 (0.48) | MEN1NPC1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL29029672 | 0.73 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1NPC1KMT2ACYP4F2 | |
| SCHEMBL1083606 | 0.73 | CPA3 (0.42) | ALDH1A1TSHRTDP1 | |
| SCHEMBL1083608 | 0.73 | CPA3 (0.42) | ALDH1A1TSHRTDP1 | |
| SCHEMBL22608475 | 0.73 | TP53 (0.49) | SMN1; SMN2NPC1KMT2AL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992550-A | Thymidylate synthetase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-02-12 | — | — | US | disclosed |