Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | MAOA | P21397 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | PTPRC | P08575 | 5/20 | 0.48 |
| ▸ | S100A4 | P26447 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | RECQL | P46063 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | APAF1 | O14727 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | TDP2 | O95551 | 2/20 | 0.48 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | PLCG1 | P19174 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3415942 | 0.92 | MAPT (0.50) | MEN1KMT2AMAOAMAPTPTPRC | |
| SCHEMBL8956362 | 0.85 | CYP1A2 (0.46) | MEN1KMT2AMAOAMAPTPTPRC | |
| SCHEMBL27551511 | 0.80 | ADORA2A (0.61) | MEN1KMT2AMAOAMAPTPTPRC | |
| SCHEMBL11312817 | 0.80 | MAOA (0.56) | MEN1KMT2AMAOAMAPTPTPRC | |
| SCHEMBL28863786 | 0.80 | PTPRC (0.46) | MEN1KMT2AMAOAMAPTPTPRC | |
| SCHEMBL3418850 | 0.80 | MEN1 (0.55) | MEN1KMT2AMAOAMAPTPTPRC | |
| SCHEMBL10599309 | 0.78 | PTGS2 (0.39) | MEN1KMT2AMAOAMAPTKDM4E | |
| SCHEMBL2072999 | 0.78 | MAPT (0.52) | MEN1KMT2AMAOAMAPTPTPRC | |
| SCHEMBL23199098 | 0.77 | PTGS2 (0.38) | MEN1KMT2AMAOAMAPTKDM4E | |
| SCHEMBL11308375 | 0.76 | ALDH1A1 (0.46) | MEN1KMT2AMAOAMAPTPTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0092385-B1 | HYDANTOIN DERIVATIVES FOR USE IN INHIBITING ALDOSE REDUCTASE ACTIVITY, COMPOSITIONS THEREFOR AND PROCESS FOR PREPARING SPIRO-FLUOREN COMPOUNDS | ALCON LABORATORIES, INC. (US) | 1991-06-12 | — | — | EP | disclosed |
| US-4540700-A | Treatment of diabetic complications with certain spiro-imidazolidine-diones | ALCON LABORATORIES, INC. (US) | 1985-09-10 | — | — | US | disclosed |
| WO-1983003543-A1 | METHOD OF INHIBITING ALDOSE REDUCTASE ACTIVITY, COMPOSITIONS THEREFOR AND PROCESS FOR PREPARING SPIRO-FLUOROFLUOREN AND SPIRO-DIFLUOROFLUOREN COMPOUNDS | ALCON LAB INC (US) | 1983-10-27 | — | — | WO | disclosed |
| EP-0092385-A2 | Hydantoin derivatives for use in inhibiting aldose reductase activity, compositions therefor and process for preparing spiro-fluoren compounds | ALCON LABORATORIES, INC. (US) | 1983-10-26 | — | — | EP | disclosed |