Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 2/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.47 |
| ▸ | CCND1 | P24385 | 2/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 4/20 | 0.37 |
| ▸ | HTR1A | P08908 | 4/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9099598 | 0.89 | MAOA (0.42) | CCNB2CDK1CDK4CCNB1CCND1 | |
| SCHEMBL9811439 | 0.86 | KDM4E (0.48) | KDM4ELMNAAPPALDH1A1HPGD | |
| SCHEMBL10428975 | 0.80 | MAPT (0.43) | LMNAHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL7089735 | 0.80 | CCNB2 (0.63) | CCNB2CDK1CDK4CCNB1CCND1 | |
| SCHEMBL10428974 | 0.78 | HTR1A (0.39) | LMNAHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL9760249 | 0.77 | SMN1; SMN2 (0.38) | KDM4EHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL9760245 | 0.75 | SMN1; SMN2 (0.41) | KDM4ELMNAHPGD | |
| SCHEMBL6584338 | 0.74 | CCNB2 (0.57) | CCNB2CDK1CDK4CCNB1CCND1 | |
| SCHEMBL6584344 | 0.74 | CCNB2 (0.57) | CCNB2CDK1CDK4CCNB1CCND1 | |
| SCHEMBL6940369 | 0.72 | MAOA (0.44) | KDM4ELMNAAPPHTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011847-A | 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists | MERCK & CO., INC. (US) | 1991-04-30 | — | — | US | disclosed |
| EP-0402156-A1 | New 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists | MERCK & CO. INC. (US) | 1990-12-12 | — | — | EP | disclosed |
| EP-0402155-A1 | New 2,5-diaryl tetrahydrofurans and analogs therof as PAF antagonists | MERCK & CO. INC. (US) | 1990-12-12 | — | — | EP | disclosed |