Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 4/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.41 |
| ▸ | TACR2 | P21452 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9692061 | 0.83 | ALDH1A1 (0.52) | MAOAMAOBKDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL9099598 | 0.83 | MAOA (0.42) | MAOAMAOBLMNAKDM4EHTR1A | |
| SCHEMBL8110374 | 0.80 | ALDH1A1 (0.47) | LMNAKDM4EL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4045055 | 0.79 | MAOA (0.57) | MAOAMAOBLMNAKDM4ETACR2 | |
| SCHEMBL11734711 | 0.79 | TACR2 (0.60) | MAOAMAOBLMNAKDM4EHTR1A | |
| SCHEMBL4621810 | 0.79 | TACR2 (0.60) | MAOAMAOBLMNAKDM4EHTR1A | |
| SCHEMBL30822591 | 0.78 | MAOA (0.56) | MAOAMAOBLMNAKDM4ETACR2 | |
| SCHEMBL1269938 | 0.78 | MAOA (0.56) | MAOAMAOBLMNAKDM4ETACR2 | |
| SCHEMBL11331941 | 0.78 | PDCD1 (0.59) | MAOAMAOBKDM4EHTR1AADRA1D | |
| SCHEMBL6942585 | 0.78 | SIRT1 (0.61) | MAOAMAOBLMNAKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1121338-A4 | METHOD FOR SYNTHESIZING DIARYL-SUBSTITUTED HETEROCYCLIC COMPOUNDS, INCLUDING TETRAHYDROFURANS | MILLENNIUM PHARM INC (US) | 2003-03-12 | — | — | EP | disclosed |
| US-20020128491-A1 | Method for synthesizing diaryl-substituted heterocyclic compounds, including tetrahydrofurans | RAO ALLA VENKATA RAMA (IN) | 2002-09-12 | — | — | US | disclosed |
| US-6403814-B1 | REACTING WITH GRIGNARD REAGENT COMPOUND HAVING CARBON SUBSTITUTED BY ACETYLENE GROUP, ARYL GROUP AND HYDROXYL GROUP, HYDROGENATING ACETYLENE MOIETY OF REACTION PRODUCT, CYCLIZING TO PROVIDE DI-ARYL TETRAHYDROFURAN | MILLENNIUM PHARMACEUTICALS, INC. | 2002-06-11 | — | — | US | disclosed |
| EP-1121338-A1 | METHOD FOR SYNTHESIZING DIARYL-SUBSTITUTED HETEROCYCLIC COMPOUNDS, INCLUDING TETRAHYDROFURANS | Millennium Pharmaceuticals, Inc. (US) | 2001-08-08 | — | — | EP | disclosed |
| WO-2000023409-A1 | METHOD FOR SYNTHESIZING DIARYL-SUBSTITUTED HETEROCYCLIC COMPOUNDS, INCLUDING TETRAHYDROFURANS | LEUKOSITE, INC. (US) | 2000-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128491-A1 | Method for synthesizing diaryl-substituted heterocyclic compounds, including tetrahydrofurans | TPMT, TPI1, GTF2I | MAOA 1212/4885MAOB 1415/4885LMNA 4124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.