Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9760249 | 0.85 | SMN1; SMN2 (0.38) | SMN1; SMN2HPGDNPC1RAB9AKDM4E | |
| SCHEMBL9100958 | 0.81 | NPC1 (0.48) | SMN1; SMN2HPGDNPC1RAB9ASMPD1 | |
| SCHEMBL10428975 | 0.79 | MAPT (0.43) | SMN1; SMN2LMNA | |
| SCHEMBL9099598 | 0.79 | MAOA (0.42) | SMN1; SMN2NPC1RAB9AKDM4ELMNA | |
| SCHEMBL9811439 | 0.79 | KDM4E (0.48) | SMN1; SMN2HPGDKDM4ELMNA | |
| SCHEMBL10428974 | 0.77 | HTR1A (0.39) | SMN1; SMN2LMNA | |
| SCHEMBL9811432 | 0.75 | CCNB2 (0.47) | HPGDKDM4ELMNA | |
| SCHEMBL27453865 | 0.74 | TNFRSF1A (0.54) | SMN1; SMN2HPGDNPC1RAB9AKDM4E | |
| SCHEMBL27472542 | 0.72 | RXRA (0.55) | SMN1; SMN2HPGDNPC1RAB9AKDM4E | |
| SCHEMBL2719972 | 0.69 | LMNA (0.56) | SMN1; SMN2HPGDNPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011847-A | 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists | MERCK & CO., INC. (US) | 1991-04-30 | — | — | US | disclosed |
| US-5001123-A | 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists | MERCK & CO., INC. (US) | 1991-03-19 | — | — | US | disclosed |
| EP-0402156-A1 | New 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists | MERCK & CO. INC. (US) | 1990-12-12 | — | — | EP | disclosed |
| EP-0402155-A1 | New 2,5-diaryl tetrahydrofurans and analogs therof as PAF antagonists | MERCK & CO. INC. (US) | 1990-12-12 | — | — | EP | disclosed |