SCHEMBL9811657

SCHEMBL9811657

C#Cc1cn([C@H]2C[C@H](OC(=O)c3ccc(Cl)cc3)[C@@H](COC(=O)c3ccc(Cl)cc3)O2)c(=O)[nH]c1=O

nearest known ligand 0.52

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
UPP1 Q16831 1/20 0.52
RNASE1 P07998 1/20 0.52
POLB P06746 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9811642 0.91 RNASE1 (0.59) UPP1RNASE1
SCHEMBL9811606 0.91 RNASE1 (0.63) UPP1RNASE1POLB
SCHEMBL9811638 0.90 RNASE1 (0.53) UPP1RNASE1
SCHEMBL9811615 0.89 TYMS (0.46)
SCHEMBL10763077 0.89 TYMS (0.46)
SCHEMBL20833584 0.88 UPP1 (0.54) UPP1RNASE1POLB
SCHEMBL5710067 0.88 RNASE1 (0.68) UPP1RNASE1
SCHEMBL6237573 0.87 RNASE1 (0.55) UPP1RNASE1
SCHEMBL7071383 0.87 RNASE1 (0.55) UPP1RNASE1
SCHEMBL9228359 0.85 LMNA (0.52) UPP1RNASE1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0208550-B1 ANTIVIRAL COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1991-05-22 EP disclosed
EP-0208550-A2 Antiviral compounds THE WELLCOME FOUNDATION LIMITED (GB) 1987-01-14 EP disclosed