Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17592852 | 0.71 | HSD11B1 (0.34) | HSD11B1HTR7APPBACE1BACE2 | |
| SCHEMBL28958880 | 0.70 | HSD11B1 (0.35) | HSD11B1APPBACE1BACE2KMT2A | |
| SCHEMBL11866512 | 0.69 | HSD11B1 (0.33) | HSD11B1LMNATSHRHTR7 | |
| SCHEMBL9813816 | 0.64 | LMNA (0.37) | HSD11B1LMNATSHRAPPBACE1 | |
| SCHEMBL2779134 | 0.64 | GAA (0.51) | HSD11B1LMNAALDH1A1GAATDP1 | |
| SCHEMBL8105682 | 0.62 | SHBG (0.31) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL6866727 | 0.61 | LMNA (0.34) | HSD11B1LMNATSHRAPPBACE1 | |
| SCHEMBL9876785 | 0.61 | LMNA (0.34) | HSD11B1LMNATSHRAPPBACE1 | |
| SCHEMBL9874539 | 0.61 | LMNA (0.34) | HSD11B1LMNATSHRAPPBACE1 | |
| SCHEMBL6866723 | 0.61 | LMNA (0.34) | HSD11B1LMNATSHRAPPBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0219199-B1 | METHOD FOR PREPARATION OF LACTONES | COULSTON INTERNATIONAL CORPORATION (US) | 1991-07-31 | — | — | EP | disclosed |
| US-4772728-A | AND ALDEHYDE | ANGUS CHEMICAL COMPANY (US) | 1988-09-20 | — | — | US | disclosed |
| EP-0219199-A1 | Method for preparation of lactones | COULSTON INTERNATIONAL CORPORATION (US) | 1987-04-22 | — | — | EP | disclosed |