Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9813673 | 0.64 | HSD11B1 (0.40) | LMNATSHRHSD11B1APPBACE1 | |
| SCHEMBL13442991 | 0.63 | ATP1A1 (0.33) | — | |
| SCHEMBL9525331 | 0.60 | — | — | |
| SCHEMBL5357561 | 0.60 | ATP1A1 (0.34) | LMNATSHR | |
| SCHEMBL3687003 | 0.60 | ATP1A1 (0.34) | LMNATSHR | |
| SCHEMBL6866727 | 0.59 | LMNA (0.34) | LMNATSHRHSD11B1APPBACE1 | |
| SCHEMBL6866723 | 0.59 | LMNA (0.34) | LMNATSHRHSD11B1APPBACE1 | |
| SCHEMBL9876785 | 0.59 | LMNA (0.34) | LMNATSHRHSD11B1APPBACE1 | |
| SCHEMBL8115022 | 0.58 | LMNA (0.41) | LMNATSHRHSD11B1APPBACE1 | |
| SCHEMBL17557382 | 0.58 | LMNA (0.33) | LMNATSHRAPPBACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0219199-B1 | METHOD FOR PREPARATION OF LACTONES | COULSTON INTERNATIONAL CORPORATION (US) | 1991-07-31 | — | — | EP | disclosed |
| US-4772728-A | AND ALDEHYDE | ANGUS CHEMICAL COMPANY (US) | 1988-09-20 | — | — | US | disclosed |
| EP-0219199-A1 | Method for preparation of lactones | COULSTON INTERNATIONAL CORPORATION (US) | 1987-04-22 | — | — | EP | disclosed |