Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 5/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | HCK | P08631 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10852036 | 1.00 | KMT2A (0.43) | KMT2AALDH1A1MEN1GAAMAPT | |
| SCHEMBL10849384 | 0.92 | ALDH1A1 (0.47) | KMT2AALDH1A1MEN1GAAMAPT | |
| SCHEMBL10849390 | 0.92 | ALDH1A1 (0.47) | KMT2AALDH1A1MEN1GAAMAPT | |
| Ralitoline SCHEMBL635346 | 0.84 | PSMD14 (0.55) | ALDH1A1GAATDP1PSMD14LCK | |
| Ralitoline SCHEMBL9813595 | 0.84 | PSMD14 (0.55) | ALDH1A1GAATDP1PSMD14LCK | |
| SCHEMBL9813551 | 0.77 | ALDH1A1 (0.59) | KMT2AALDH1A1MEN1GAAMAPT | |
| SCHEMBL9813552 | 0.77 | ALDH1A1 (0.59) | KMT2AALDH1A1MEN1GAAMAPT | |
| SCHEMBL9813560 | 0.76 | LMNA (0.49) | KMT2AALDH1A1MAPTTDP1PSMD14 | |
| SCHEMBL9813563 | 0.76 | LMNA (0.49) | KMT2AALDH1A1MAPTTDP1PSMD14 | |
| SCHEMBL9813566 | 0.76 | PSMD14 (0.61) | KMT2AALDH1A1MEN1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0124911-B1 | 4-OXO-THIAZOLIDIN-2-YLIDEN-ACETAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICAMENTS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM ILLNESSES CONTAINING THEM | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1991-07-31 | — | — | EP | disclosed |
| US-4563471-A | CENTRAL NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 1986-01-07 | — | — | US | disclosed |
| EP-0124911-A2 | 4-Oxo-thiazolidin-2-yliden-acetamide derivatives, process for their preparation, and medicaments for the treatment of central nervous system illnesses containing them | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1984-11-14 | — | — | EP | disclosed |