SCHEMBL9813824

SCHEMBL9813824

O=C(O)Cc1ccc(CCCS(=O)(=O)c2cccc(Cl)c2)cc1

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.48
HDAC8 Q9BY41 1/20 0.48
TBXA2R P21731 1/20 0.47
ALDH1A1 P00352 2/20 0.45
HPGD P15428 1/20 0.45
HSD17B10 Q99714 1/20 0.45
ADRB1 P08588 1/20 0.45
ADRB3 P13945 1/20 0.45
CPT1A P50416 2/20 0.44
CPT1B Q92523 2/20 0.44
EGLN1 Q9GZT9 1/20 0.44
FBP1 P09467 6/20 0.44
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C19 P33261 1/20 0.42
GAA P10253 1/20 0.42
PTGDR2 Q9Y5Y4 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9813753 0.84 HDAC1 (0.64) HDAC1HDAC8TBXA2RALDH1A1HPGD
SCHEMBL3250400 0.83 TBXA2R (0.62) HDAC1HDAC8TBXA2RALDH1A1HPGD
SCHEMBL9813803 0.81 POLB (0.54) HDAC1HDAC8HPGDCYP3A4CYP2D6
SCHEMBL10583477 0.80 ALDH1A1 (0.50) HDAC1HDAC8ALDH1A1HPGDHSD17B10
SCHEMBL9813790 0.80 HDAC1 (0.47) HDAC1HDAC8TBXA2RALDH1A1HPGD
SCHEMBL10581074 0.80 HDAC1 (0.58) HDAC1HDAC8TBXA2RALDH1A1HPGD
SCHEMBL10584188 0.79 TBXA2R (0.60) HDAC1HDAC8TBXA2RALDH1A1HPGD
SCHEMBL9813464 0.78 PTGES (0.53) HDAC1HDAC8ALDH1A1HPGDHSD17B10
SCHEMBL10583129 0.78 TBXA2R (0.52) HDAC1HDAC8TBXA2RALDH1A1GAA
SCHEMBL10580163 0.77 TBXAS1 (0.54) HDAC1HDAC8PTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0301421-B1 SULFUR COMPOUNDS, PROCESS FOR THEIR PREPARATION AND MEDICINES Roche Diagnostics GmbH (DE) 1991-08-28 EP claimed
EP-0301421-B1 SULFUR COMPOUNDS, PROCESS FOR THEIR PREPARATION AND MEDICINES Roche Diagnostics GmbH (DE) 1991-08-28 EP disclosed
EP-0301421-A2 Sulfur compounds, process for their preparation and medicines Roche Diagnostics GmbH (DE) 1989-02-01 EP disclosed