Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9814140 | 0.83 | PARP1 (0.49) | MAOBKDM4ECA1CA2ACHE | |
| SCHEMBL6520422 | 0.82 | MAOA (0.53) | MAOAMAOBL3MBTL1MEN1KMT2A | |
| SCHEMBL9814134 | 0.76 | CA1 (0.51) | CA1CA2SIGMAR1 | |
| SCHEMBL8857004 | 0.74 | ADRA1A (0.43) | KDM4ECA1CA2ACHEADRA1A | |
| SCHEMBL10751929 | 0.74 | ADRA1A (0.40) | CA1CA2ADRA1ASIGMAR1 | |
| SCHEMBL21091907 | 0.73 | KMT2A (0.51) | MAOAMAOBKDM1AL3MBTL1MEN1 | |
| SCHEMBL21091908 | 0.73 | KMT2A (0.51) | MAOAMAOBKDM1AL3MBTL1MEN1 | |
| SCHEMBL9814133 | 0.71 | MAOB (0.37) | MAOAMAOBACHEHTR1AADRA1D | |
| SCHEMBL5713193 | 0.70 | ALDH1A1 (0.54) | MAOAMAOBBCHEKDM4EAGTR2 | |
| SCHEMBL8857197 | 0.70 | NPSR1 (0.42) | KDM4EL3MBTL1CA1CA2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166937-B1 | ADRENERGIC COMPOUNDS | ABBOTT LABORATORIES (US) | 1991-08-28 | — | — | EP | disclosed |
| US-4634705-A | Adrenergic amidines | ABBOTT LABORATORIES (US) | 1987-01-06 | — | — | US | disclosed |
| EP-0166937-A2 | Adrenergic compounds | ABBOTT LABORATORIES (US) | 1986-01-08 | — | — | EP | disclosed |