Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL6258274 | 0.86 | TP53 (0.39) | TSHRSLC1A3SLC1A2SLC1A1TP53 | |
| Propene SCHEMBL4290931 | 0.83 | TSHR (0.35) | TSHRTP53ALDH1A1 | |
| Isobutane SCHEMBL27894360 | 0.80 | LMNA (0.41) | TSHRLMNATP53ALDH1A1 | |
| Bicarbonate SCHEMBL28800487 | 0.80 | LMNA (0.41) | TSHRLMNAALDH1A1HCAR2 | |
| Bicarbonate SCHEMBL5134303 | 0.78 | HCAR2 (0.36) | TSHRLMNAALDH1A1HCAR2 | |
| Isopropyl Alcohol SCHEMBL6154477 | 0.77 | TP53 (0.44) | TSHRLMNATP53ALDH1A1 | |
| Acetic Acid SCHEMBL10711426 | 0.77 | FFAR3 (0.47) | TSHRLMNASLC1A3SLC1A2SLC1A1 | |
| Acrylamide SCHEMBL28449014 | 0.77 | TSHR (0.55) | TSHRLMNASLC1A3SLC1A2SLC1A1 | |
| Bicarbonate SCHEMBL226943 | 0.76 | LMNA (0.50) | TSHRLMNATP53ALDH1A1 | |
| Bicarbonate SCHEMBL21612732 | 0.76 | LMNA (0.50) | TSHRLMNATP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5039582-A | High energy and high power lithium storage batteries, and method for producing the same | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 1991-08-13 | — | — | US | disclosed |
| EP-0009934-B1 | MANGANESE DIOXIDE, METHOD FOR ITS MANUFACTURE AND ELECTROCHEMICAL CELL HAVING CATHODE CONTAINING SAID MANGANESE DIOXIDE | UNION CARBIDE CORPORATION (US) | 1982-11-03 | — | — | EP | disclosed |
| US-4321314-A | Non-aqueous cell safety | DURACELL INTERNATIONAL INC. (US) | 1982-03-23 | — | — | US | disclosed |
| US-4312930-A | MANGANESE DIOXIDE FROM LITHIUM MANGANATE SPINEL | UNION CARBIDE CORPORATION (US) | 1982-01-26 | — | — | US | disclosed |